Zhang Hongwei, Di Jianzhong, Yu Haoyong, Han Xiaodong, Li Kun, Zhang Pin
Department of General Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, 200233, China.
Obes Surg. 2015 Jul;25(7):1263-70. doi: 10.1007/s11695-015-1666-y.
The study aimed to examine the effect of gastric bypass on diabetic nephropathy (DN) in Chinese patients. A retrospective study of 101 samples with DN stages I to IV underwent Roux-en-Y gastric bypass. Anthropometric and biochemical parameters were assessed during a 1-year follow-up. Binary logistic regression analysis was used for predictors and ROC for cutoff points. There was significant reduction of medication for diabetes and hypertension. Overall remission of T2DM was 80.2 %. Preoperative albumin/creatinine ratio (ACR) and serum creatinine (SCr) levels could be predictors for DN remission, and the cutoff points were 126 mg/g cr and 57 μmol/L, respectively. Gastric bypass showed improvement of T2DM and DN. Gastric bypass may be more beneficial for those with lower preoperative ACR and SCr.
该研究旨在探讨胃旁路手术对中国糖尿病肾病（DN）患者的影响。对101例I至IV期DN患者进行了回顾性研究，这些患者接受了Roux-en-Y胃旁路手术。在1年的随访期间评估了人体测量和生化参数。采用二元逻辑回归分析预测因素，采用ROC分析确定切点。糖尿病和高血压药物用量显著减少。2型糖尿病的总体缓解率为80.2%。术前白蛋白/肌酐比值（ACR）和血清肌酐（SCr）水平可作为DN缓解的预测指标，切点分别为126 mg/g cr和57 μmol/L。胃旁路手术改善了2型糖尿病和DN。胃旁路手术可能对术前ACR和SCr较低的患者更有益。
