Ribeiro Moço V J, Lopes A J, Vigário P dos Santos, de Almeida V P, de Menezes S L S, Guimarães F S
Rehabilitation Science Graduate Program, Augusto Motta University, Rio de Janeiro, Brazil.
Rehabilitation Science Graduate Program, Augusto Motta University, Rio de Janeiro, Brazil; Department of Physical Therapy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Rev Port Pneumol (2006). 2015 Jul-Aug;21(4):198-202. doi: 10.1016/j.rppnen.2014.10.003. Epub 2015 Feb 16.
As there are few studies on the impact of respiratory and functional status on the quality of life domains in adults with cystic fibrosis, this study aimed to evaluate the association between respiratory function, functional capacity and quality of life in these subjects.
This is a cross-sectional study, where adults with clinical and laboratorial diagnoses of CF fibrosis underwent pulmonary function tests, the six-minute walk distance test (6MWT) and responded to the Cystic Fibrosis Questionnaire-Revised (CFQ-R). Descriptive statistics was used to summarize the findings. The associations were tested by means of Pearson's or Spearman tests, and the significance level was set at 5%.
The 21 patients who completed the study presented with reduced quality of life in all CFQ-R domains, obstructive pulmonary disease and reduced 6MWT distance. The following associations were found between pulmonary function and CFQ-R domains: forced vital capacity - FVC (%) and treatment burden and digestive symptoms (r=-0.433, p<0.05; r=-0.443, p<0.05, respectively), forced expiratory volume in one second - FVC ratio - FEV1/FVC (%) and physical functioning, social and respiratory symptoms (r=0.5, p<0.05; r=0.58, p<0.01; r=0.45, p<0.05, respectively), residual volume (%) and physical functioning (r=0.49, p<0.05), airways' resistance - Raw and physical functioning and emotional functioning (r=-0.44, p<0.05; r=-0,46, p<0.05, respectively), carbon monoxide diffusing capacity (%pred) and physical functioning (r=-0,51; p<0.05).
Adults with CF have reduced quality of life, which in part is associated with the severity of their lung function.
由于关于呼吸和功能状态对成年囊性纤维化患者生活质量领域影响的研究较少，本研究旨在评估这些受试者的呼吸功能、功能能力与生活质量之间的关联。
这是一项横断面研究，临床和实验室诊断为囊性纤维化的成年患者接受了肺功能测试、六分钟步行距离测试（6MWT），并对囊性纤维化问卷修订版（CFQ-R）做出回应。采用描述性统计来总结研究结果。通过Pearson检验或Spearman检验来测试关联，显著性水平设定为5%。
完成研究的21名患者在所有CFQ-R领域的生活质量均下降，存在阻塞性肺病且6MWT距离缩短。在肺功能与CFQ-R领域之间发现了以下关联：用力肺活量 - FVC（%）与治疗负担和消化症状（分别为r = -0.433，p < 0.05；r = -0.443，p < 0.05），一秒用力呼气容积 - FVC比值 - FEV1/FVC（%）与身体功能、社交和呼吸症状（分别为r = 0.5，p < 0.05；r = 0.58，p < 0.01；r = 0.45，p < 0.05），残气量（%）与身体功能（r = 0.49，p < 0.05）。气道阻力 - Raw与身体功能和情绪功能（分别为r = -0.44，p < 0.05；r = -0.46，p < 0.05），一氧化碳弥散量（%pred）与身体功能（r = -0.51；p < 0.05）。
成年囊性纤维化患者生活质量下降，部分原因与他们肺功能的严重程度有关。
