Hernández-Núñez Jónathan, Valdés-Yong Magel
Department of Obstetrics and Gynecology, Hospital Alberto Fernández-Valdés, Santa Cruz del Norte, Mayabeque, Cuba.
Department of Obstetrics and Gynecology, Hospital Luis Díaz Soto, Habana del Este, La Habana, Cuba.
Int J Womens Health. 2015 Apr 13;7:385-91. doi: 10.2147/IJWH.S79577. eCollection 2015.
The study of proteomics could explain many aspects of obstetric disorders. We undertook this review with the aim of assessing the utility of proteomics in the specialty of obstetrics. We searched the electronic databases of MEDLINE, EBSCOhost, BVS Bireme, and SciELO, using various search terms with the assistance of a librarian. We considered cohort studies, case-control studies, case series, and systematic review articles published until October 2014 in the English or Spanish language, and evaluated their quality and the internal validity of the evidence provided. Two reviewers extracted the data independently, then both researchers simultaneously revised the data later, to arrive at a consensus. The search retrieved 1,158 papers, of which 965 were excluded for being duplicates, not relevant, or unrelated studies. A further 86 papers were excluded for being guidelines, protocols, or case reports, along with another 64 that did not contain relevant information, leaving 43 studies for inclusion. Many of these studies showed the utility of proteomic techniques for prediction, pathophysiology, diagnosis, management, monitoring, and prognosis of pre-eclampsia, perinatal infection, premature rupture of membranes, preterm birth, intrauterine growth restriction, and ectopic pregnancy. Proteomic techniques have enormous clinical significance and constitute an invaluable weapon in the management of obstetric disorders that increase maternal and perinatal morbidity and mortality.
蛋白质组学研究可以解释产科疾病的许多方面。我们进行这项综述的目的是评估蛋白质组学在产科专业中的实用性。我们在图书馆员的协助下，使用各种检索词搜索了MEDLINE、EBSCOhost、BVS Bireme和SciELO的电子数据库。我们纳入了截至2014年10月发表的英文或西班牙文队列研究、病例对照研究、病例系列和系统评价文章，并评估了它们的质量和所提供证据的内部有效性。两名评审员独立提取数据，随后两名研究人员同时对数据进行修订，以达成共识。检索到1158篇论文，其中965篇因重复、不相关或无关研究而被排除。另有86篇论文因是指南、方案或病例报告而被排除，还有64篇不包含相关信息，最终纳入43项研究。这些研究中有许多显示了蛋白质组学技术在子痫前期、围产期感染、胎膜早破、早产、胎儿生长受限和异位妊娠的预测、病理生理学、诊断、管理、监测和预后方面的实用性。蛋白质组学技术具有巨大的临床意义，是管理增加孕产妇和围产期发病率及死亡率的产科疾病的宝贵武器。
