鲨鱼体内广泛的逆转录病毒多样性。
Extensive retroviral diversity in shark.
作者信息
Han Guan-Zhu
机构信息
Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, 210023, China.
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, 85719, USA.
出版信息
Retrovirology. 2015 Apr 28;12:34. doi: 10.1186/s12977-015-0158-4.
BACKGROUND
Retroviruses infect a wide range of vertebrates. However, little is known about the diversity of retroviruses in basal vertebrates. Endogenous retrovirus (ERV) provides a valuable resource to study the ecology and evolution of retrovirus.
FINDINGS
I performed a genome-scale screening for ERVs in the elephant shark (Callorhinchus milii) and identified three complete or nearly complete ERVs and many short ERV fragments. I designate these retroviral elements "C. milli ERVs" (CmiERVs). Phylogenetic analysis shows that the CmiERVs form three distinct lineages. The genome invasions by these retroviruses are estimated to take place more than 50 million years ago.
CONCLUSIONS
My results reveal the extensive retroviral diversity in the elephant shark. Diverse retroviruses appear to have been associated with cartilaginous fishes for millions of years. These findings have important implications in understanding the diversity and evolution of retroviruses.
背景
逆转录病毒可感染多种脊椎动物。然而，对于基础脊椎动物中逆转录病毒的多样性了解甚少。内源性逆转录病毒（ERV）为研究逆转录病毒的生态和进化提供了宝贵资源。
研究结果
我对姥鲨（Callorhinchus milii）的ERV进行了全基因组规模筛选，鉴定出三个完整或近乎完整的ERV以及许多短ERV片段。我将这些逆转录病毒元件命名为“姥鲨ERV”（CmiERVs）。系统发育分析表明，CmiERVs形成三个不同的谱系。据估计，这些逆转录病毒对基因组的入侵发生在5000多万年前。
结论
我的研究结果揭示了姥鲨中广泛的逆转录病毒多样性。数百万年来，多种逆转录病毒似乎一直与软骨鱼类有关。这些发现对于理解逆转录病毒的多样性和进化具有重要意义。
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