Aldo-Benson M, Borel H, Scheiderer-Pratt L, Borel Y
Department of Medicine, Indiana University School of Medicine, Indianapolis.
Immunol Res. 1989;8(4):263-70. doi: 10.1007/BF02935511.
We examine whether B cell lines enriched for DNA specificity from either autoimmune (BWF1) or normal mice (Balb/c) can be rendered unresponsive to autoantigen in terms of the specific suppression of direct antibody-forming cells to DNA. These B cell lines were both Lyt-1 positive and negative. Preincubation with oligonucleotide, covalently linked to mouse gamma-globulin, specifically suppressed the antigen-driven response elicited by DNA horse red blood cells in B cell lines from both strains of mice. There is a 5-fold difference in susceptibility to DNA-specific tolerance induction between B cell lines of BWF1 and Balb/c mice. Thus, B cells from autoimmune mice do not appear to have an inherent absolute defect in being rendered tolerant to autoantigen, but are relatively less susceptible to DNA-specific tolerance than nonautoimmune cell lines.
我们研究了从自身免疫小鼠（BWF1）或正常小鼠（Balb/c）中富集的具有DNA特异性的B细胞系，就直接抗DNA抗体形成细胞的特异性抑制而言，是否能使其对自身抗原无反应。这些B细胞系既有Lyt-1阳性的，也有Lyt-1阴性的。与小鼠γ球蛋白共价连接的寡核苷酸预孵育，可特异性抑制两种小鼠品系B细胞系中由DNA马红细胞引发的抗原驱动反应。BWF1小鼠和Balb/c小鼠的B细胞系在对DNA特异性耐受诱导的敏感性上存在5倍差异。因此，自身免疫小鼠的B细胞在对自身抗原产生耐受方面似乎并没有内在的绝对缺陷，只是与非自身免疫细胞系相比，对DNA特异性耐受相对不敏感。
