迈克尔反应：软碳亲核试剂与异恶唑-5-亚烷基酮的加成反应——β-支链羰基化合物的一种多样化合成方法
Michael Addition of Soft Carbon Nucleophiles to Alkylidene Isoxazol-5-ones: A Divergent Entry to β-Branched Carbonyl Compounds.
作者信息
Capreti Naylil M R, Jurberg Igor D
机构信息
Institute of Chemistry, State University of Campinas, 13083-970, C.P. 6154, Campinas, SP, Brazil.
出版信息
Org Lett. 2015 May 15;17(10):2490-3. doi: 10.1021/acs.orglett.5b01004. Epub 2015 Apr 30.
PMID:25928191
Abstract
A novel, divergent strategy toward the synthesis of β-branched (and linear) carbonyl compounds is developed by taking advantage of alkylidene isoxazol-5-ones as key building blocks. The yields obtained range from good to excellent, therefore making the described methods attractive options for building such molecules.
摘要
通过利用亚烷基异恶唑-5-酮作为关键构建单元，开发了一种新颖、不同的合成β-支链（和直链）羰基化合物的策略。所获得的产率从良好到优异不等，因此使得所描述的方法成为构建此类分子的有吸引力的选择。
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