载脂蛋白C3基因rs5128多态性与血浆载脂蛋白C3及血脂水平的关联：一项荟萃分析

Associations of the APOC3 rs5128 polymorphism with plasma APOC3 and lipid levels: a meta-analysis.

作者信息

Song Yongyan, Zhu Liren, Richa Mudwari, Li Ping, Yang Yang, Li Suping

机构信息

Department of Medical Biochemistry, School of Preclinical Medicine, North Sichuan Medical College, Nanchong, 637000, P R. China.

School of Clinical Medicine, North Sichuan Medical College, Nanchong, 637000, P R. China.

出版信息

Lipids Health Dis. 2015 Apr 18;14:32. doi: 10.1186/s12944-015-0027-0.

BACKGROUND

Studies of the association between the apolipoprotein C3 gene (APOC3) rs5128 polymorphism and plasma levels of apolipoprotein C3 (APOC3) and lipids have reported apparently conflicting findings. This meta-analysis aimed to investigate the associations of the rs5128 polymorphism with fasting APOC3 and lipid levels.

METHODS

The following information was abstracted for each study: ethnicity, age, sex, health condition, sample size, genotyping and lipid assay methods, mean and standard deviation or standard error by genotypes for APOC3 and lipid variables. There were 42 eligible studies with 23846 subjects included in this meta-analysis. A dominant model was used for this meta-analysis.

RESULTS

The results showed that the carriers of the variant allele G had higher levels of APOC3 [standardized mean difference (SMD): 0.22, 95% confidence interval (CI): 0.12-0.31, P<0.00001], triglycerides (TG) (SMD: 0.33, 95% CI: 0.23-0.44, P<0.00001), total cholesterol (TC) (SMD: 0.15, 95% CI: 0.09-0.22, P<0.00001), and low-density lipoprotein cholesterol (LDL-C) (SMD: 0.11, 95% CI: 0.04-0.17, P=0.001) than the non-carriers. No significant association between the APOC3 rs5128 polymorphism and lower levels of high-density lipoprotein cholesterol (HDL-C) was detected under the dominant model (SMD: -0.03, 95% CI: -0.06-0.01, P=0.156).

CONCLUSIONS

The results from the present meta-analysis demonstrate a significant association between the APOC3 rs5128 polymorphism and higher levels of APOC3, TG, TC and LDL-C, but further studies are needed to elucidate the underlying mechanisms.

背景

关于载脂蛋白C3基因（APOC3）rs5128多态性与载脂蛋白C3（APOC3）血浆水平及血脂之间关联的研究报告了明显相互矛盾的结果。本荟萃分析旨在研究rs5128多态性与空腹APOC3及血脂水平之间的关联。

方法

为每项研究提取以下信息：种族、年龄、性别、健康状况、样本量、基因分型和血脂检测方法、APOC3和血脂变量按基因型的均值及标准差或标准误。本荟萃分析纳入了42项符合条件的研究，共23846名受试者。本荟萃分析采用显性模型。

结果

结果显示，变异等位基因G的携带者的APOC3水平[标准化均数差（SMD）：0.22，95%置信区间（CI）：0.12 - 0.31，P < 0.00001]、甘油三酯（TG）（SMD：0.33，95% CI：0.23 - 0.44，P < 0.00001）、总胆固醇（TC）（SMD：0.15，95% CI：0.09 - 0.22，P < 0.00001）和低密度脂蛋白胆固醇（LDL - C）（SMD：0.11，95% CI：0.04 - 0.17，P = 0.001）均高于非携带者。在显性模型下，未检测到APOC3 rs5128多态性与高密度脂蛋白胆固醇（HDL - C）水平降低之间存在显著关联（SMD： - 0.03，95% CI： - 0.06 - 0.01，P = 0.156）。