Department of Traditional Chinese Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People's Republic of China.
Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People's Republic of China.
Lipids Health Dis. 2017 Sep 6;16(1):166. doi: 10.1186/s12944-017-0558-7.
The associations of the apolipoprotein B gene (APOB) rs693 and rs17240441 polymorphisms with plasma levels of APOB and lipids have been widely explored, but the results were inconclusive. This meta-analysis aimed to clarify the associations of the rs693 and rs17240441 polymorphisms with fasting APOB and lipid levels.
Sixty-one studies (50,018 subjects) and 23 studies (8425 subjects) were respectively identified for the rs693 and rs17240441 polymorphisms by searching in PubMed, Google Scholar, Web of Science, Cochrane Library, Wanfang, VIP and CNKI databases. The following information was collected for each study: first author, age, gender, ethnicity, health condition, sample size, genotyping, lipid assay method, mean and standard deviation or standard error of APOB and lipid variables by genotypes. A dominant model was used for this meta-analysis.
The carriers of the rs693 variant allele (T) had higher levels of APOB [standardized mean difference (SMD) = 0.26, 95% confidence interval (CI) = 0.16-0.36, P < 0.01], triglycerides (TG) (SMD = 0.12, 95% CI = 0.05-0.20, P < 0.01), total cholesterol (TC) (SMD = 0.24, 95% CI = 0.17-0.30, P < 0.01) and low-density lipoprotein cholesterol (LDL-C) (SMD = 0.22, 95% CI = 0.14-0.30, P < 0.01), and lower levels of high-density lipoprotein cholesterol (HDL-C) (SMD = -0.06, 95% CI = -0.11-0.01, P = 0.01) than the non-carriers. The carriers of the rs17240441 deletion allele had higher levels of APOB (SMD = 0.13, 95% CI = 0.06-0.20, P < 0.01), TC (SMD = 0.17, 95% CI = 0.07-0.26, P < 0.01) and LDL-C (SMD = 0.15, 95% CI = 0.07-0.23, P < 0.01) than the non-carriers.
The rs693 polymorphism is significantly associated with higher levels of APOB, TG, TC and LDL-C, and lower levels of HDL-C. The rs17240441 polymorphism is significantly associated with higher levels of APOB, TC and LDL-C. Further studies are needed to elucidate the underlying mechanisms.
载脂蛋白 B 基因（APOB）rs693 和 rs17240441 多态性与 APOB 和血脂的血浆水平之间的关联已被广泛研究，但结果尚无定论。本荟萃分析旨在阐明 rs693 和 rs17240441 多态性与空腹 APOB 和血脂水平的关系。
通过在 PubMed、Google Scholar、Web of Science、Cochrane Library、万方、VIP 和中国知网数据库中搜索，分别确定了 61 项研究（50018 例受试者）和 23 项研究（8425 例受试者）与 rs693 和 rs17240441 多态性相关。对于每个研究，收集了以下信息：第一作者、年龄、性别、种族、健康状况、样本量、基因分型、血脂检测方法、按基因型计算的 APOB 和血脂变量的平均值和标准差或标准误。本荟萃分析采用显性模型。
rs693 变异等位基因（T）携带者的 APOB 水平较高[标准化均数差（SMD）=0.26，95%置信区间（CI）=0.16-0.36，P<0.01]，甘油三酯（TG）（SMD=0.12，95%CI=0.05-0.20，P<0.01）、总胆固醇（TC）（SMD=0.24，95%CI=0.17-0.30，P<0.01）和低密度脂蛋白胆固醇（LDL-C）（SMD=0.22，95%CI=0.14-0.30，P<0.01），高密度脂蛋白胆固醇（HDL-C）水平较低（SMD=-0.06，95%CI=-0.11-0.01，P=0.01）。rs17240441 缺失等位基因携带者的 APOB 水平较高（SMD=0.13，95%CI=0.06-0.20，P<0.01），TC（SMD=0.17，95%CI=0.07-0.26，P<0.01）和 LDL-C（SMD=0.15，95%CI=0.07-0.23，P<0.01）水平高于非携带者。
rs693 多态性与 APOB、TG、TC 和 LDL-C 水平升高以及 HDL-C 水平降低显著相关。rs17240441 多态性与 APOB、TC 和 LDL-C 水平升高显著相关。需要进一步的研究来阐明潜在的机制。
