Correa Livia L, Neto Leonardo Vieira, Lima Giovanna A Balarini, Gabrich Rafael, Miranda Luiz Carlos D de, Gadelha Monica R
Endocrinology Service, University Hospital Clementino Fraga Filho (HUCFF), Universidade Federal do Rio de Janeiro, RJ, Brazil.
Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione (IEDE), Rio de Janeiro, RJ, Brazil.
Int Braz J Urol. 2015 Jan-Feb;41(1):110-5. doi: 10.1590/S1677-5538.IBJU.2015.01.15.
Non-androgenic growth factors are involved in the growth regulation of prostate cancer (PCa).
This is the first Brazilian study to correlate, in a population of patients operated for PCa, PSA, total testosterone, insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding protein-3 (IGFBP-3) with Gleason score and to compare with a control group with benign prostate hyperplasia (BPH).
This retrospective single-center study included 49 men with previously diagnosed PCa and 45 with previously diagnosed BPH. PSA, testosterone, IGF-I, IGFBP-3 were determined in both groups.
PSA and IGFBP-3 levels were significantly higher in the PCa group as compared to the BPH group (p < 0.001 and p=0.004, respectively). There was a significant difference when we compared the PSA before surgery (p < 0.001) and at the inclusion in the study (p < 0.001) and IGFBP3 (0.016) among patients with Gleason < 7, ≥7 and BPH. In the PCa group, PSA, testosterone, IGF-I and IGFBP-3 levels were comparable between Gleason < 7 and ≥7.
Our data suggest that in localized PCa, the quantification of PSA and, not of IGF-1, may provide independent significant information in the aggressiveness. IGFBP-3 could be a biochemical marker of disease control in PCa patients.
非雄激素生长因子参与前列腺癌（PCa）的生长调节。
这是巴西的第一项研究，在接受PCa手术的患者群体中，将前列腺特异性抗原（PSA）、总睾酮、胰岛素样生长因子-I（IGF-I）和胰岛素样生长因子结合蛋白-3（IGFBP-3）与 Gleason评分相关联，并与良性前列腺增生（BPH）对照组进行比较。
这项回顾性单中心研究纳入了49例先前诊断为PCa的男性和45例先前诊断为BPH的男性。两组均测定了PSA、睾酮、IGF-I、IGFBP-3。
与BPH组相比，PCa组的PSA和IGFBP-3水平显著更高（分别为p < 0.001和p = 0.004）。在Gleason评分<7、≥7的患者与BPH患者之间比较术前PSA（p < 0.001）、研究纳入时的PSA（p < 0.001）和IGFBP3（0.016）时，存在显著差异。在PCa组中，Gleason评分<7和≥7的患者之间，PSA、睾酮、IGF-I和IGFBP-3水平相当。
我们的数据表明，在局限性PCa中，PSA的定量而非IGF-1的定量可能在侵袭性方面提供独立的重要信息。IGFBP-3可能是PCa患者疾病控制的生化标志物。
