任务类型通过重复导航经颅磁刺激映射影响语言阳性皮质区域的位置。
Task type affects location of language-positive cortical regions by repetitive navigated transcranial magnetic stimulation mapping.
作者信息
Hauck Theresa, Tanigawa Noriko, Probst Monika, Wohlschlaeger Afra, Ille Sebastian, Sollmann Nico, Maurer Stefanie, Zimmer Claus, Ringel Florian, Meyer Bernhard, Krieg Sandro M
机构信息
Department of Neurosurgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Faculty of Linguistics, Philology, and Phonetics, University of Oxford, Oxford, United Kingdom.
出版信息
PLoS One. 2015 Apr 30;10(4):e0125298. doi: 10.1371/journal.pone.0125298. eCollection 2015.
OBJECTIVES
Recent repetitive TMS (rTMS) mapping protocols for language mapping revealed deficits of this method, mainly in posterior brain regions. Therefore this study analyzed the impact of different language tasks on the localization of language-positive brain regions and compared their effectiveness, especially with regard to posterior brain regions.
METHODS
Nineteen healthy, right-handed subjects performed object naming, pseudoword reading, verb generation, and action naming during rTMS language mapping of the left hemisphere. Synchronically, 5 Hz/10 pulses were applied with a 0 ms delay.
RESULTS
The object naming task evoked the highest error rate (14%), followed by verb generation (13%) and action naming (11%). The latter revealed more errors in posterior than in anterior areas. Pseudoword reading barely generated errors, except for phonological paraphasias.
CONCLUSIONS
In general, among the evaluated language tasks, object naming is the most discriminative task to detect language-positive regions via rTMS. However, other tasks might be used for more specific questions.
目的
近期用于语言映射的重复经颅磁刺激（rTMS）映射方案显示了该方法的不足之处，主要存在于大脑后部区域。因此，本研究分析了不同语言任务对语言阳性脑区定位的影响，并比较了它们的有效性，特别是在大脑后部区域方面。
方法
19名健康的右利手受试者在左半球rTMS语言映射期间执行物体命名、假词阅读、动词生成和动作命名任务。同时，以0毫秒的延迟施加5赫兹/10个脉冲。
结果
物体命名任务诱发的错误率最高（14%），其次是动词生成（13%）和动作命名（11%）。动作命名在后部区域比在前部区域出现更多错误。假词阅读除了语音性错语外几乎不产生错误。
结论
总体而言，在所评估的语言任务中，物体命名是通过rTMS检测语言阳性区域最具区分性的任务。然而，其他任务可能用于更具体的问题。
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