酒精醋在抑制念珠菌属中的应用及其对丙烯酸树脂物理性能的影响。
Use of alcohol vinegar in the inhibition of Candida spp. and its effect on the physical properties of acrylic resins.
作者信息
de Castro Ricardo Dias, Mota Ana Carolina Loureiro Gama, de Oliveira Lima Edeltrudes, Batista André Ulisses Dantas, de Araújo Oliveira Julyana, Cavalcanti Alessandro Leite
机构信息
Graduate Program in Dentistry, Universidade Federal da Paraíba, Campus I, João Pessoa, Paraíba, 58.051-900, Brazil.
João Pessoa University Center, João Pessoa, Paraíba, Brazil.
出版信息
BMC Oral Health. 2015 Apr 28;15:52. doi: 10.1186/s12903-015-0035-5.
BACKGROUND
Given the high prevalence of oral candidiasis and the restricted number of antifungal agents available to control infection, this study investigated the in vitro antifungal activity of alcohol vinegar on Candida spp. and its effect on the physical properties of acrylic resins.
METHODS
Tests to determine the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) of vinegar alcohol (0.04 g/ml of acetic acid) and nystatin (control) were performed. The antifungal activity of alcohol vinegar was assessed through microbial growth kinetic assays and inhibition of Candida albicans adhesion to acrylic resin at different intervals of time. Surface roughness and color of the acrylic resin were analyzed using a roughness meter and color analyzer device.
RESULTS
Alcohol vinegar showed MIC75% and MFC62.5% of 2.5 mg/ml, with fungicidal effect from 120 min, differing from nystatin (p < 0.0001), which showed fungistatic effect. Alcohol vinegar caused greater inhibition of C. albicans adhesion to the acrylic resin (p ≤ 0.001) compared to nystatin and did not change the roughness and color parameters of the material.
CONCLUSION
Alcohol vinegar showed antifungal properties against Candida strains and caused no physical changes to the acrylic resin.
背景
鉴于口腔念珠菌病的高发病率以及可用于控制感染的抗真菌药物数量有限，本研究调查了酒精醋对念珠菌属的体外抗真菌活性及其对丙烯酸树脂物理性能的影响。
方法
进行了测试以确定酒精醋（0.04 g/ml 乙酸）和制霉菌素（对照）的最低抑菌浓度（MIC）和最低杀菌浓度（MFC）。通过微生物生长动力学测定以及在不同时间间隔抑制白色念珠菌对丙烯酸树脂的粘附来评估酒精醋的抗真菌活性。使用粗糙度仪和颜色分析仪对丙烯酸树脂的表面粗糙度和颜色进行分析。
结果
酒精醋的 MIC75%和 MFC62.5%为 2.5 mg/ml，在 120 分钟时具有杀菌作用，这与制霉菌素不同（p < 0.0001），制霉菌素表现出抑菌作用。与制霉菌素相比，酒精醋对白色念珠菌粘附到丙烯酸树脂的抑制作用更强（p ≤ 0.001），并且没有改变材料的粗糙度和颜色参数。
结论
酒精醋对念珠菌菌株具有抗真菌特性，并且不会对丙烯酸树脂造成物理变化。
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