Marcoux S, Brisson J, Fabia J
Department of Social and Preventive Medicine, Laval University, Quebec, Canada.
J Epidemiol Community Health. 1989 Jun;43(2):147-52. doi: 10.1136/jech.43.2.147.
To assess the relation between leisure time physical activity (LTPA) during the first 20 weeks of pregnancy and the risk of developing pre-eclampsia and gestational hypertension.
Case-control study carried out over a 28 month period with retrospective data collection.
Six hospitals in Quebec City and four hospitals in Montreal.
172 women with pre-eclampsia, 254 with gestational diabetes, 505 controls. All were primiparous, with no history of high blood pressure before pregnancy (unless due to oral contraceptive use), or during the first 20 weeks of gestation. Cases were defined using recognised criteria, and 97% of those eligible agreed to be interviewed. Controls delivered in same hospital immediately after cases and had no more than one reading of elevated blood pressure during pregnancy; 96% of those eligible agreed to be interviewed.
Participants were interviewed in hospital a few days after delivery using a questionnaire. Information was collected on type, frequency and average duration of any LTPA performed regularly during the first 20 weeks of pregnancy, together with medical, obstetric and sociodemographic details. It was found that women who performed regular LTPA had a reduced risk of pre-eclampsia (adjusted RR 0.67, 95% CI 0.46-0.96) and gestational hypertension (aRR 0.75, 95% CI 0.54-1.05), and the relative risks decreased as the average time spent in LTPA increased (aRR for pre-eclampsia among women with low, moderate and high energy expenditure: 1.00, 0.77 and 0.57, p = 0.01). The same trend was present for gestational hypertension (1.00, 0.80 and 0.71, respectively, p = 0.08).
Leisure time physical activity during the first half of pregnancy is likely to reduce the risk of pre-eclampsia and gestational hypertension.
评估妊娠前20周的休闲时间体力活动（LTPA）与子痫前期和妊娠期高血压发病风险之间的关系。
一项为期28个月的病例对照研究，采用回顾性数据收集方法。
魁北克市的六家医院和蒙特利尔的四家医院。
172例子痫前期患者、254例妊娠期糖尿病患者、505例对照者。所有参与者均为初产妇，妊娠前（除非因使用口服避孕药）或妊娠前20周内无高血压病史。病例根据公认标准定义，97%符合条件的患者同意接受访谈。对照者在病例之后立即在同一家医院分娩，妊娠期血压升高读数不超过一次；96%符合条件的对照者同意接受访谈。
参与者在产后几天在医院接受问卷调查。收集了妊娠前20周定期进行的任何LTPA的类型、频率和平均持续时间信息，以及医学、产科和社会人口学详细信息。结果发现，进行定期LTPA的女性患子痫前期（校正风险比0.67，95%置信区间0.46 - 0.96）和妊娠期高血压（校正风险比0.75，95%置信区间0.54 - 1.05）的风险降低，并且随着LTPA平均时间的增加，相对风险降低（低、中、高能量消耗女性子痫前期的校正风险比分别为1.00、0.77和0.57，p = 0.01）。妊娠期高血压也呈现相同趋势（分别为1.00、0.80和0.71，p = 0.08）。
妊娠前半期的休闲时间体力活动可能会降低子痫前期和妊娠期高血压的风险。
