Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Department of Neurology, Oregon Health and Science University, Portland, OR, USA.
Eur J Neurol. 2015 Jul;22(7):1138-41. doi: 10.1111/ene.12722. Epub 2015 Apr 29.
The lack of surrogates of clinical progression has limited the design of neuroprotection trials in multiple sclerosis (MS). Our aim was to study the association between time-domain optical coherence tomography measures and clinical and magnetic resonance imaging outcomes in early MS.
Forty-three relapsing-remitting MS patients within 1 year of onset were followed for up to 3 years.
The peripapillary retinal nerve fiber layer (RNFL) decreased annually by 2 μm (95% confidence interval -3.89, -0.11; P = 0.038). The RNFL tended to be associated with normalized normal appearing white matter volume in cross-sectional (P = 0.08) and longitudinal analyses (P = 0.06).
There is substantial RNFL loss even in very early MS. Our data suggest that retinal axonal atrophy is associated with atrophy in global white matter volume in early MS.
缺乏临床进展的替代指标限制了多发性硬化症（MS）的神经保护试验设计。我们的目的是研究时域光相干断层扫描（OCT）测量值与早期 MS 的临床和磁共振成像（MRI）结果之间的关系。
43 例发病 1 年内的复发缓解型 MS 患者进行了长达 3 年的随访。
视盘周围视网膜神经纤维层（RNFL）每年减少 2μm（95%置信区间-3.89，-0.11；P=0.038）。RNFL 在横断面（P=0.08）和纵向分析（P=0.06）中与正常表现白质体积的校正呈相关性。
即使在非常早期的 MS 中，RNFL 也会大量丢失。我们的数据表明，视网膜轴突萎缩与早期 MS 中全球白质体积的萎缩相关。
