妇科恶性肿瘤中的血清鳞状细胞癌抗原，特别提及宫颈癌。

Serum squamous cell carcinoma antigen in gynecologic malignancies with special reference to cervical cancer.

作者信息

Hsieh C Y, Chang D Y, Huang S C, Yen M L, Juang G T, Ouyang P C

出版信息

Taiwan Yi Xue Hui Za Zhi. 1989 Aug;88(8):797-800.

Abstract

Squamous cell carcinoma (SCC) antigen was measured by double-antibody radioimmunoassay in the sera of 113 patients with gynecologic malignancies and 30 controls. The mean serum SCC antigen level was 9.24 ng/ml in those with cervical squamous cell carcinoma, 2.15 ng/ml in those with other gynecologic malignancies, and 1.25 ng/ml in controls. With a cutoff value of 2.23 ng/ml (2 SD above the mean of the control group), the rate of SCC antigen elevation was 54% in cervical cancer (78), 14% in vulvar or vaginal cancer (7), 22% in ovarian cancer (18), and 10% in endometrial cancer (10). In cervical squamous cell carcinoma, the rates of elevated SCC antigen level increased with disease advancement in stages 0, I, II, III, and IV, by 13, 50, 53, 78, and 100%, respectively. In early-stage cervical squamous cell carcinoma, SCC antigen was not sensitive enough for screening. However, if elevated, serum SCC antigen levels decreased rapidly after successful surgical treatment. One case with a serum SCC antigen level above 65 multiples of the cutoff value had widespread cancer and postoperative recurrence. In the advanced case, the sensitivity was much higher. In the recurrent case, the positive rate was 73%. Serum SCC antigen level is useful in predicting the prognosis and monitoring the course of cervical squamous cell carcinoma, especially in the detection of a recurrence.

摘要

采用双抗体放射免疫分析法检测了113例妇科恶性肿瘤患者和30例对照者血清中的鳞状细胞癌（SCC）抗原。宫颈鳞状细胞癌患者血清SCC抗原平均水平为9.24 ng/ml，其他妇科恶性肿瘤患者为2.15 ng/ml，对照者为1.25 ng/ml。以2.23 ng/ml（高于对照组均值2个标准差）为临界值，宫颈癌（78例）中SCC抗原升高率为54%，外阴或阴道癌（7例）中为14%，卵巢癌（18例）中为22%，子宫内膜癌（10例）中为10%。在宫颈鳞状细胞癌中，0、I、II、III和IV期SCC抗原水平升高率随疾病进展而增加，分别为13%、50%、53%、78%和100%。在早期宫颈鳞状细胞癌中，SCC抗原用于筛查的敏感性不足。然而，如果升高，成功手术治疗后血清SCC抗原水平会迅速下降。1例血清SCC抗原水平高于临界值65倍的患者存在广泛癌症且术后复发。在晚期病例中，敏感性更高。在复发病例中，阳性率为73%。血清SCC抗原水平有助于预测宫颈鳞状细胞癌的预后和监测病程，尤其是在检测复发方面。