印度红蝎（金蝎）蜇伤中毒儿童心肌功能障碍的预测因素
Predictors of Myocardial Dysfunction in Children with Indian Red Scorpion (Mesobuthus tamulus) Sting Envenomation.
作者信息
Kumar P M Ananda, Krishnamurthy Sriram, Srinivasaraghavan Rangan, Mahadevan Subramanian, Harichandrakumar K T
机构信息
Departments of Pediatrics and *Biostatistics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India Correspondence to: Dr Subramanian Mahadevan, Professor, Department of Pediatrics, JIPMER, Pondicherry 605 006, India.
出版信息
Indian Pediatr. 2015 Apr;52(4):297-301. doi: 10.1007/s13312-015-0627-9.
OBJECTIVE
To identify predictive risk factors for myocardial dysfunction in children with scorpion sting envenomation and to evaluate the effects of Scorpion antivenom and prazosin combination therapy on occurrence of myocardial dysfunction.
DESIGN
Observational.
SETTING
Tertiary care hospital in Southern India.
PARTICIPANTS
85 children aged <13 years with scorpion sting envenomation.
OUTCOME MEASURES
Frequency of myocardial dysfunction; predictors of myocardial dysfunction.
RESULTS
24 children (28.2%) developed myocardial dysfunction. Hypotension at admission (P=0.003) and increased time (>4h) between sting and administration of appropriate therapy (P=0.001) were independent predictors of myocardial dysfunction on logistic regression. Scorpion antivenom plus prazosin combination therapy led to an increase in cumulative proportion of children without myocardial dysfunction.
CONCLUSIONS
Early (<4 hours) administration of Scorpion antivenom along with prazosin increases the cumulative percentage of children not developing myocardial dysfunction.
目的
确定蝎蜇伤儿童心肌功能障碍的预测风险因素，并评估抗蝎毒血清与哌唑嗪联合治疗对心肌功能障碍发生的影响。
设计
观察性研究。
地点
印度南部的三级护理医院。
参与者
85名年龄小于13岁的蝎蜇伤儿童。
观察指标
心肌功能障碍的发生率；心肌功能障碍的预测因素。
结果
24名儿童（28.2%）出现心肌功能障碍。入院时低血压（P=0.003）以及蜇伤与给予适当治疗之间的时间延长（>4小时）（P=0.001）是逻辑回归中心肌功能障碍的独立预测因素。抗蝎毒血清加哌唑嗪联合治疗导致无心肌功能障碍儿童的累积比例增加。
结论
早期（<4小时）给予抗蝎毒血清联合哌唑嗪可增加未发生心肌功能障碍儿童的累积百分比。
Zotero 插件