Elderson A, Gerritsen van der Hoop R, Haanstra W, Neijt J P, Gispen W H, Jennekens F G
Department of Neurology, University of Utrecht, The Netherlands.
J Neurol Sci. 1989 Nov;93(2-3):167-74. doi: 10.1016/0022-510x(89)90187-1.
In 20 ovarian cancer patients treated by cisplatin-based chemotherapy quantitative investigations of the vibration and the thermoperception were performed. Following the administration of cisplatin of 300 mg/m2 and more the vibration perception threshold (VPT) was shown to be significantly elevated in all patients, despite the absence of clinical symptoms and signs in a number of patients. The VPT returned within 8 months to its original level in the 2 patients who were followed after cessation of therapy (cumulative dose of cisplatin 450-525 mg/m2). The changes seen in hands and in feet were comparable. There was no significant difference between the left and the right hand side. Thermoperception thresholds did not change during the treatment period. This study shows that quantitative measurement of vibration perception thresholds in patients treated with cisplatin is a relatively simple, accurate and reliable technique. Measurement is only required at the hand. It is concluded that this technique is a valuable tool in the assessment of cisplatin neurotoxicity and may be used in the monitoring of drugs that claim to be of benefit in the prevention and treatment of this affliction.
对20例接受以顺铂为基础的化疗的卵巢癌患者进行了振动觉和温度觉的定量研究。给予300mg/m²及以上顺铂后，所有患者的振动觉阈值（VPT）均显著升高，尽管一些患者没有临床症状和体征。在停止治疗后随访的2例患者（顺铂累积剂量450 - 525mg/m²）中，VPT在8个月内恢复到原来水平。手部和足部的变化相似。左右手之间无显著差异。治疗期间温度觉阈值未发生变化。本研究表明，对接受顺铂治疗的患者进行振动觉阈值的定量测量是一种相对简单、准确且可靠的技术。仅需测量手部。结论是，该技术是评估顺铂神经毒性的有价值工具，可用于监测声称对预防和治疗这种疾病有益的药物。
