Vandertop W P, de Vries W B, Notermans N C, Nijsen M J, de Wildt D J, Tulleken C A, Gispen W H
Department of Neurosurgery, Rudolf Magnus Institute and University Hospital, Utrecht, The Netherlands.
J Neurooncol. 1996 Jan;27(1):53-60. doi: 10.1007/BF00146084.
The neurotoxic side-effects of cisplatin affect predominantly the large, myelinated fibres of peripheral nerves, leading to a sensory neuropathy. Several reports of cisplatin-associated autonomic neuropathy have been published. Autonomic dysfunction however, is caused by a neuropathy of small unmyelinated nerve fibres. By using the absolute pupil diameter as a parameter of autonomic nervous system function, we studied autonomic neuropathy in the eye of cisplatin-intoxicated rats. In addition, we examined autonomic cardiovascular function by measuring the change in heart rate (HR) and mean arterial blood pressure (MAP) in response to intravenous phenylephrine (PHE) and tyramine (TYR). No significant differences in mean pupil diameter developed in cisplatin-intoxicated rats (n = 12) in the course of 9 weeks (total cumulative dose cisplatin 18 mg/kg) compared with normal controls (n = 9) MANOVA, F1,19 = 0.88, P < 0.36). The PHE- and TYR-induced changes in MAP and HR were virtually the same in cisplatin-intoxicated rats when compared with normal controls. We conclude that cisplatin probably does not cause autonomic dysfunction, at least not in rats, in doses commonly used and which are known to cause a peripheral sensory neuropathy.
顺铂的神经毒性副作用主要影响外周神经的大型有髓纤维，导致感觉神经病变。已有多篇关于顺铂相关自主神经病变的报道发表。然而，自主神经功能障碍是由小型无髓神经纤维的神经病变引起的。通过使用绝对瞳孔直径作为自主神经系统功能的参数，我们研究了顺铂中毒大鼠眼部的自主神经病变。此外，我们通过测量静脉注射去氧肾上腺素（PHE）和酪胺（TYR）后心率（HR）和平均动脉血压（MAP）的变化来检查自主心血管功能。与正常对照组（n = 9）相比，顺铂中毒大鼠（n = 12）在9周内（顺铂总累积剂量18 mg/kg）平均瞳孔直径没有显著差异（多变量方差分析，F1,19 = 0.88，P < 0.36）。与正常对照组相比，顺铂中毒大鼠中PHE和TYR诱导的MAP和HR变化几乎相同。我们得出结论，顺铂可能不会导致自主神经功能障碍，至少在常用剂量且已知会导致外周感觉神经病变的大鼠中不会。
