Shimazu R, Raju S, Fujiwara H, Grogan J B
Department of Surgery/Transplantation, University of Mississippi Medical Center, Jackson 39216-4505.
J Pediatr Surg. 1989 Dec;24(12):1253-7. doi: 10.1016/s0022-3468(89)80562-7.
Alternative combined immunosuppressive therapy was tested in canine orthotopic bowel transplantation. Despite sporadic long-term survival, cyclosporine is still questionably effective. Triple-drug therapy (cyclosporine, azathioprine, and prednisone) combined with antilymphocyte serum or with a short segment graft was effective in reducing the early postoperative mortality due to acute rejection but did not alter the long-term survival rate. There was no apparent relationship between the serum cyclosporine levels and survival. The long-term survivors (longer than 100 days) maintained relatively low serum trough levels of cyclosporine. These suggest that orthotopic bowel transplantation in the dog, and probably in the human as well, requires improved immunosuppressive regimens.
在犬原位肠移植中对替代联合免疫抑制疗法进行了测试。尽管有零星的长期存活情况，但环孢素的有效性仍存在疑问。三联药物疗法（环孢素、硫唑嘌呤和泼尼松）联合抗淋巴细胞血清或短节段移植物在降低急性排斥所致的术后早期死亡率方面有效，但并未改变长期存活率。血清环孢素水平与存活率之间没有明显关系。长期存活者（超过100天）的环孢素血清谷值水平相对较低。这些表明犬的原位肠移植，可能人类的原位肠移植也一样，需要改进免疫抑制方案。
