Kaiser Ursula B
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA.
Cell Res. 2015 Jun;25(6):649-50. doi: 10.1038/cr.2015.53. Epub 2015 May 1.
The pathogenesis of Cushing's disease is poorly understood; two recent reports identifying somatic mutations in USP8 in pituitary corticotroph tumors provide exciting advances in this field. These mutations alter EGFR trafficking and signaling, raising the prospect that EGFR inhibitors may move the treatment of this disease into the era of precision medicine.
库欣病的发病机制尚不清楚；最近有两份报告指出垂体促肾上腺皮质激素肿瘤中USP8存在体细胞突变，这为该领域带来了令人振奋的进展。这些突变改变了表皮生长因子受体（EGFR）的运输和信号传导，这使得EGFR抑制剂有望将这种疾病的治疗带入精准医学时代。
