A novel human tumoroid 3D model of sustained ACTH-secreting cell cultures to study critically needed therapies for Cushing's disease.
作者信息
Fuentes-Fayos Antonio C, Luque Raúl M
机构信息
Maimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Cordoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain; Reina Sofia University Hospital (HURS), 14004 Cordoba, Spain; CIBER Physiopathology of Obesity and Nutrition (CIBERobn), 14004 Cordoba, Spain.
Maimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Cordoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain; Reina Sofia University Hospital (HURS), 14004 Cordoba, Spain; CIBER Physiopathology of Obesity and Nutrition (CIBERobn), 14004 Cordoba, Spain.
出版信息
EBioMedicine. 2021 May;67:103368. doi: 10.1016/j.ebiom.2021.103368. Epub 2021 May 13.
Abstract
摘要
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A novel human tumoroid 3D model of sustained ACTH-secreting cell cultures to study critically needed therapies for Cushing's disease.一种新型的人类类肿瘤三维模型，用于持续分泌促肾上腺皮质激素细胞培养，以研究库欣病急需的治疗方法。
EBioMedicine. 2021 May;67:103368. doi: 10.1016/j.ebiom.2021.103368. Epub 2021 May 13.
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本文引用的文献
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A human ACTH-secreting corticotroph tumoroid model: Novel Human ACTH-Secreting Tumor Cell in vitro Model.人 ACTH 分泌细胞肿瘤模型：新型人 ACTH 分泌肿瘤细胞体外模型。
EBioMedicine. 2021 Apr;66:103294. doi: 10.1016/j.ebiom.2021.103294. Epub 2021 Mar 25.
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The Epidemiology of Pituitary Adenomas.《垂体腺瘤的流行病学》
Endocrinol Metab Clin North Am. 2020 Sep;49(3):347-355. doi: 10.1016/j.ecl.2020.04.002. Epub 2020 Jun 10.
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Novel Insights into Pituitary Tumorigenesis: Genetic and Epigenetic Mechanisms.垂体肿瘤发生的新见解：遗传和表观遗传机制。
Endocr Rev. 2020 Dec 1;41(6):821-46. doi: 10.1210/endrev/bnaa006.
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Pituitary-Tumor Endocrinopathies.垂体肿瘤内分泌病
N Engl J Med. 2020 Mar 5;382(10):937-950. doi: 10.1056/NEJMra1810772.
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Mouse models of endocrine tumors.内分泌肿瘤的小鼠模型
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Multiple signaling pathways convey central and peripheral signals to regulate pituitary function: Lessons from human and non-human primate models.多种信号通路将中枢和外周信号传递到调节垂体功能：来自人类和非人灵长类动物模型的经验教训。
Mol Cell Endocrinol. 2018 Mar 5;463:4-22. doi: 10.1016/j.mce.2017.12.007. Epub 2017 Dec 16.
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Cushing's disease: towards precision medicine.库欣病：迈向精准医学
Cell Res. 2015 Jun;25(6):649-50. doi: 10.1038/cr.2015.53. Epub 2015 May 1.
8
A cellular and molecular basis for the selective desmopressin-induced ACTH release in Cushing disease patients: key role of AVPR1b receptor and potential therapeutic implications.库欣病患者选择性去氨加压素诱导 ACTH 释放的细胞和分子基础：AVPR1b 受体的关键作用及潜在治疗意义。
J Clin Endocrinol Metab. 2013 Oct;98(10):4160-9. doi: 10.1210/jc.2013-1992. Epub 2013 Jul 24.
9
A Serum-Free System for Primary Cultures of Human Pituitary Adenomas.一种用于人垂体腺瘤原代培养的无血清系统。
Endocr Pathol. 1995 Winter;6(4):289-299. doi: 10.1007/BF02738729.
10
Long-term culture of human corticotropin-secreting adenomas on extracellular matrix and evaluation of serum-free conditions. Morphological aspects.人促肾上腺皮质激素分泌腺瘤在细胞外基质上的长期培养及无血清条件评估。形态学方面。
Acta Neuropathol. 1986;71(1-2):142-9. doi: 10.1007/BF00687976.
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