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A novel human tumoroid 3D model of sustained ACTH-secreting cell cultures to study critically needed therapies for Cushing's disease.

作者信息

Fuentes-Fayos Antonio C, Luque Raúl M

机构信息

Maimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Cordoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain; Reina Sofia University Hospital (HURS), 14004 Cordoba, Spain; CIBER Physiopathology of Obesity and Nutrition (CIBERobn), 14004 Cordoba, Spain.

Maimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Cordoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain; Reina Sofia University Hospital (HURS), 14004 Cordoba, Spain; CIBER Physiopathology of Obesity and Nutrition (CIBERobn), 14004 Cordoba, Spain.

出版信息

EBioMedicine. 2021 May;67:103368. doi: 10.1016/j.ebiom.2021.103368. Epub 2021 May 13.

DOI:10.1016/j.ebiom.2021.103368
PMID:33993049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8206815/
Abstract
摘要

相似文献

1
A novel human tumoroid 3D model of sustained ACTH-secreting cell cultures to study critically needed therapies for Cushing's disease.一种新型的人类类肿瘤三维模型，用于持续分泌促肾上腺皮质激素细胞培养，以研究库欣病急需的治疗方法。
EBioMedicine. 2021 May;67:103368. doi: 10.1016/j.ebiom.2021.103368. Epub 2021 May 13.
2
No effect of the PPAR-gamma agonist rosiglitazone on ACTH or cortisol secretion in Nelson's syndrome and Cushing's disease in vitro and in vivo.过氧化物酶体增殖物激活受体γ激动剂罗格列酮对尼尔森综合征和库欣病患者促肾上腺皮质激素或皮质醇分泌在体内外均无影响。
Clin Neuropathol. 2009 Nov-Dec;28(6):430-9.
3
PPAR-gamma in Cushing's disease.库欣病中的过氧化物酶体增殖物激活受体γ
Pituitary. 2004;7(4):265-9. doi: 10.1007/s11102-005-1430-8.
4
The Ectopic Adrenocorticotropic Hormone Syndrome: Rarely Easy, Always Challenging.异位促肾上腺皮质激素综合征：罕见简单，却始终充满挑战。
Endocrinol Metab Clin North Am. 2018 Jun;47(2):409-425. doi: 10.1016/j.ecl.2018.01.005.
5
Repeated remissions of Cushing's disease due to recurrent infarctions of an ACTH-producing pituitary macroadenoma.促肾上腺皮质激素分泌型垂体大腺瘤反复梗死导致库欣病反复缓解。
Pituitary. 2005;8(2):81-7. doi: 10.1007/s11102-005-2961-8.
6
New types of localization methods for adrenocorticotropic hormone-dependent Cushing's syndrome.促肾上腺皮质激素依赖性库欣综合征的新型定位方法。
Best Pract Res Clin Endocrinol Metab. 2021 Jan;35(1):101513. doi: 10.1016/j.beem.2021.101513. Epub 2021 Mar 10.
7
Pathophysiology and treatment of subclinical Cushing's disease and pituitary silent corticotroph adenomas [Review].亚临床库欣病和垂体无功能促肾上腺皮质激素腺瘤的病理生理学与治疗 [综述]
Endocr J. 2014;61(10):941-8. doi: 10.1507/endocrj.ej14-0120. Epub 2014 Jun 29.
8
Reduction of a pancreatic tumor after total removal of an ACTH secreting pituitary tumor: differential diagnosis of Cushing's syndrome.促肾上腺皮质激素分泌型垂体瘤全切术后胰腺肿瘤缩小：库欣综合征的鉴别诊断
Endocr J. 2006 Apr;53(2):203-8. doi: 10.1507/endocrj.53.203.
9
Prolactin correction for adequacy of petrosal sinus cannulation may diminish diagnostic accuracy in Cushing's disease.岩下窦插管充分性校正催乳素可能会降低库欣病的诊断准确性。
Clin Endocrinol (Oxf). 2017 Nov;87(5):515-522. doi: 10.1111/cen.13401. Epub 2017 Jul 24.
10
Mitotane reduces human and mouse ACTH-secreting pituitary cell viability and function.米托坦降低人源和鼠源 ACTH 分泌型垂体细胞活力和功能。
J Endocrinol. 2013 Jul 29;218(3):275-85. doi: 10.1530/JOE-13-0210. Print 2013 Sep.

本文引用的文献

1
A human ACTH-secreting corticotroph tumoroid model: Novel Human ACTH-Secreting Tumor Cell in vitro Model.人 ACTH 分泌细胞肿瘤模型：新型人 ACTH 分泌肿瘤细胞体外模型。
EBioMedicine. 2021 Apr;66:103294. doi: 10.1016/j.ebiom.2021.103294. Epub 2021 Mar 25.
2
The Epidemiology of Pituitary Adenomas.《垂体腺瘤的流行病学》
Endocrinol Metab Clin North Am. 2020 Sep;49(3):347-355. doi: 10.1016/j.ecl.2020.04.002. Epub 2020 Jun 10.
3
Novel Insights into Pituitary Tumorigenesis: Genetic and Epigenetic Mechanisms.垂体肿瘤发生的新见解：遗传和表观遗传机制。
Endocr Rev. 2020 Dec 1;41(6):821-46. doi: 10.1210/endrev/bnaa006.
4
Pituitary-Tumor Endocrinopathies.垂体肿瘤内分泌病
N Engl J Med. 2020 Mar 5;382(10):937-950. doi: 10.1056/NEJMra1810772.
5
Mouse models of endocrine tumors.内分泌肿瘤的小鼠模型
J Endocrinol. 2019 Mar;240(3):R73-R96. doi: 10.1530/JOE-18-0571.
6
Multiple signaling pathways convey central and peripheral signals to regulate pituitary function: Lessons from human and non-human primate models.多种信号通路将中枢和外周信号传递到调节垂体功能：来自人类和非人灵长类动物模型的经验教训。
Mol Cell Endocrinol. 2018 Mar 5;463:4-22. doi: 10.1016/j.mce.2017.12.007. Epub 2017 Dec 16.
7
Cushing's disease: towards precision medicine.库欣病：迈向精准医学
Cell Res. 2015 Jun;25(6):649-50. doi: 10.1038/cr.2015.53. Epub 2015 May 1.
8
A cellular and molecular basis for the selective desmopressin-induced ACTH release in Cushing disease patients: key role of AVPR1b receptor and potential therapeutic implications.库欣病患者选择性去氨加压素诱导 ACTH 释放的细胞和分子基础：AVPR1b 受体的关键作用及潜在治疗意义。
J Clin Endocrinol Metab. 2013 Oct;98(10):4160-9. doi: 10.1210/jc.2013-1992. Epub 2013 Jul 24.
9
A Serum-Free System for Primary Cultures of Human Pituitary Adenomas.一种用于人垂体腺瘤原代培养的无血清系统。
Endocr Pathol. 1995 Winter;6(4):289-299. doi: 10.1007/BF02738729.
10
Long-term culture of human corticotropin-secreting adenomas on extracellular matrix and evaluation of serum-free conditions. Morphological aspects.人促肾上腺皮质激素分泌腺瘤在细胞外基质上的长期培养及无血清条件评估。形态学方面。
Acta Neuropathol. 1986;71(1-2):142-9. doi: 10.1007/BF00687976.