散发性胰腺癌的早期检测：综述

Early detection of sporadic pancreatic cancer: summative review.

作者信息

Chari Suresh T, Kelly Kimberly, Hollingsworth Michael A, Thayer Sarah P, Ahlquist David A, Andersen Dana K, Batra Surinder K, Brentnall Teresa A, Canto Marcia, Cleeter Deborah F, Firpo Matthew A, Gambhir Sanjiv Sam, Go Vay Liang W, Hines O Joe, Kenner Barbara J, Klimstra David S, Lerch Markus M, Levy Michael J, Maitra Anirban, Mulvihill Sean J, Petersen Gloria M, Rhim Andrew D, Simeone Diane M, Srivastava Sudhir, Tanaka Masao, Vinik Aaron I, Wong David

机构信息

From the *Department of Medicine, Mayo Clinic, Rochester, MN; †Department of Biomedical Engineering, University of Virginia, Charlottesville, VA; Departments of ‡Biochemistry and Molecular Biology, §Pathology and Microbiology, and ∥Surgery, Fred & Pamela Buffett Cancer Center, University of Nebraska, Omaha, NE; ¶Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD; #Division of Gastroenterology, University of Washington, Seattle, WA; **Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, MD; ††Sawgrass Leadership Institute, Ponte Vedra Beach, FL; ‡‡Department of Surgery, University of Utah, Salt Lake City, UT; §§Department of Radiology, Stanford University School of Medicine, Stanford; ∥∥Department of Medicine, David Geffen School of Medicine, and ¶¶General Surgery, University of California Los Angeles, Los Angeles, CA; ##Kenner Family Research Fund; ***Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY; †††Department of Internal Medicine, University of Greifswald, Greifswald, Germany; ‡‡‡Division of Pathology and Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston, TX; §§§Department of Health Sciences Research, Mayo Clinic, Rochester, MN; ∥∥∥Gastroenterology Division, Department of Internal Medicine and Comprehensive Cancer Center, and ¶¶¶Department of Surgery, School of Medicine, University of Michigan, Ann Arbor, MI; ###Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, MD; ****Departments of Surgery and Oncology, Kyushu University, Fukuoka, Japan; ††††Department of Medicine, Eastern Virginia Medical School, Norfolk, VA; and ‡‡‡‡Division of Oral Biology and Medicine, CLA School of Dentistry, Jonnson Comprehensive Cancer Center, University of California Los Angeles, L

出版信息

Pancreas. 2015 Jul;44(5):693-712. doi: 10.1097/MPA.0000000000000368.

DOI:10.1097/MPA.0000000000000368

PMID:25931254

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4467589/

Abstract

Pancreatic cancer (PC) is estimated to become the second leading cause of cancer death in the United States by 2020. Early detection is the key to improving survival in PC. Addressing this urgent need, the Kenner Family Research Fund conducted the inaugural Early Detection of Sporadic Pancreatic Cancer Summit Conference in 2014 in conjunction with the 45th Anniversary Meeting of the American Pancreatic Association and Japan Pancreas Society. This seminal convening of international representatives from science, practice, and clinical research was designed to facilitate challenging interdisciplinary conversations to generate innovative ideas leading to the creation of a defined collaborative strategic pathway for the future of the field. An in-depth summary of current efforts in the field, analysis of gaps in specific areas of expertise, and challenges that exist in early detection is presented within distinct areas of inquiry: Case for Early Detection: Definitions, Detection, Survival, and Challenges; Biomarkers for Early Detection; Imaging; and Collaborative Studies. In addition, an overview of efforts in familial PC is presented in an addendum to this article. It is clear from the summit deliberations that only strategically designed collaboration among investigators, institutions, and funders will lead to significant progress in early detection of sporadic PC.

摘要

据估计，到2020年胰腺癌将成为美国癌症死亡的第二大主要原因。早期检测是提高胰腺癌患者生存率的关键。为满足这一迫切需求，肯纳家族研究基金于2014年与美国胰腺协会和日本胰腺学会第45届年会联合举办了首届散发性胰腺癌早期检测峰会。这次由来自科学、实践和临床研究领域的国际代表参加的开创性会议旨在促进具有挑战性的跨学科对话，以产生创新想法，从而为该领域的未来创建明确的合作战略路径。本文在不同的探究领域中，对该领域当前的工作进行了深入总结，分析了特定专业领域的差距以及早期检测中存在的挑战：早期检测的理由：定义、检测、生存率及挑战；早期检测的生物标志物；成像；以及合作研究。此外，本文附录中还概述了家族性胰腺癌的研究工作。从峰会的讨论中可以清楚地看出，只有研究人员、机构和资助者之间进行精心设计的战略合作，才会在散发性胰腺癌的早期检测方面取得重大进展。