启动子DNA甲基化与上皮性卵巢癌中KLF11的表达相关。
Promoter DNA methylation is associated with KLF11 expression in epithelial ovarian cancer.
作者信息
Wang Guan, Li Xianfeng, Tian Weiping, Wang Yan, Wu Dandan, Sun Zhongsheng, Zhao Enfeng
机构信息
Department of Obstetrics and Gynecology, Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin, 300100, China.
State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410078, China.
出版信息
Genes Chromosomes Cancer. 2015 Jul;54(7):453-62. doi: 10.1002/gcc.22257. Epub 2015 Apr 30.
As a transforming growth factor-β (TGF-β)-inducible gene, the expression of Krüppel-like transcription factor 11 (KLF11) is altered in several types of cancer. In the current study, through using human 9K CpG island array, KLF11 was identified as one of hypermethylated genes in RAS-transformed ovarian T29H cells. Methylation of the KLF11 promoter was also observed in ovarian cancer tissue samples accompanied by significantly reduced KLF11 gene expression. Interestingly, the expression of SMAD2, SMAD3, and SMAD7 genes was reduced in the tumour, whilst no change was found in TGF-β expression. Our data suggest a relationship between promoter DNA methylation and KLF11 gene expression in ovarian cancer tumorigenesis.
作为一种转化生长因子-β（TGF-β）诱导基因，Krüppel样转录因子11（KLF11）的表达在几种类型的癌症中发生改变。在当前研究中，通过使用人类9K CpG岛阵列，KLF11被鉴定为RAS转化的卵巢T29H细胞中的高甲基化基因之一。在卵巢癌组织样本中也观察到KLF11启动子的甲基化，同时KLF11基因表达显著降低。有趣的是，肿瘤中SMAD2、SMAD3和SMAD7基因的表达降低，而TGF-β表达未发现变化。我们的数据表明在卵巢癌发生过程中启动子DNA甲基化与KLF11基因表达之间存在关联。
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