神经肽数据库：神经肽的综合资源库。
NeuroPep: a comprehensive resource of neuropeptides.
作者信息
Wang Yan, Wang Mingxia, Yin Sanwen, Jang Richard, Wang Jian, Xue Zhidong, Xu Tao
机构信息
Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, School of Software Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, School of Software Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, School of Software Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
出版信息
Database (Oxford). 2015 Apr 29;2015:bav038. doi: 10.1093/database/bav038. Print 2015.
Neuropeptides play a variety of roles in many physiological processes and serve as potential therapeutic targets for the treatment of some nervous-system disorders. In recent years, there has been a tremendous increase in the number of identified neuropeptides. Therefore, we have developed NeuroPep, a comprehensive resource of neuropeptides, which holds 5949 non-redundant neuropeptide entries originating from 493 organisms belonging to 65 neuropeptide families. In NeuroPep, the number of neuropeptides in invertebrates and vertebrates is 3455 and 2406, respectively. It is currently the most complete neuropeptide database. We extracted entries deposited in UniProt, the database (www.neuropeptides.nl) and NeuroPedia, and used text mining methods to retrieve entries from the MEDLINE abstracts and full text articles. All the entries in NeuroPep have been manually checked. 2069 of the 5949 (35%) neuropeptide sequences were collected from the scientific literature. Moreover, NeuroPep contains detailed annotations for each entry, including source organisms, tissue specificity, families, names, post-translational modifications, 3D structures (if available) and literature references. Information derived from these peptide sequences such as amino acid compositions, isoelectric points, molecular weight and other physicochemical properties of peptides are also provided. A quick search feature allows users to search the database with keywords such as sequence, name, family, etc., and an advanced search page helps users to combine queries with logical operators like AND/OR. In addition, user-friendly web tools like browsing, sequence alignment and mapping are also integrated into the NeuroPep database. Database URL: http://isyslab.info/NeuroPep
神经肽在许多生理过程中发挥着多种作用，并作为治疗某些神经系统疾病的潜在治疗靶点。近年来，已鉴定的神经肽数量大幅增加。因此，我们开发了NeuroPep，这是一个全面的神经肽资源库，包含来自65个神经肽家族的493种生物的5949个非冗余神经肽条目。在NeuroPep中，无脊椎动物和脊椎动物的神经肽数量分别为3455和2406。它是目前最完整的神经肽数据库。我们提取了存于UniProt、数据库（www.neuropeptides.nl）和NeuroPedia中的条目，并使用文本挖掘方法从MEDLINE摘要和全文文章中检索条目。NeuroPep中的所有条目都经过了人工检查。5949个神经肽序列中的2069个（35%）是从科学文献中收集的。此外，NeuroPep包含每个条目的详细注释，包括来源生物、组织特异性、家族、名称、翻译后修饰、三维结构（如果可用）和文献参考。还提供了从这些肽序列衍生的信息，如氨基酸组成、等电点、分子量和肽的其他物理化学性质。快速搜索功能允许用户使用序列、名称、家族等关键词搜索数据库，高级搜索页面帮助用户使用AND/OR等逻辑运算符组合查询。此外，NeuroPep数据库还集成了浏览、序列比对和映射等用户友好的网络工具。数据库网址：http://isyslab.info/NeuroPep
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