Glickman L T, Schofer F S, McKee L J, Reif J S, Goldschmidt M H
Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, Philadelphia.
J Toxicol Environ Health. 1989;28(4):407-14. doi: 10.1080/15287398909531360.
A case-control study of household dogs was conducted to determine if exposure to sidestream cigarette smoke and chemicals in the home, use of topical insecticides, and obesity are associated with the occurrence of bladder cancer. Information was obtained by interview from owners of 59 dogs with transitional-cell carcinoma of the bladder and 71 age- and breed size-matched control dogs with other chronic diseases or neoplasms. Bladder cancer risk was unrelated to sidestream cigarette smoke and household chemical exposures. Risk was significantly increased by topical insecticide use (OR = 1.6 for 1-2 applications per year and OR = 3.5 for greater than 2 applications per year; chi 2 trend; p = .008). This risk was enhanced in overweight or obese dogs. Further studies of this canine model may facilitate identification of specific carcinogens present in insecticides commonly used on pet animals and in the environment.
开展了一项针对家犬的病例对照研究，以确定接触室内侧流香烟烟雾和化学物质、使用局部杀虫剂以及肥胖是否与膀胱癌的发生有关。通过访谈，从59只患有膀胱移行细胞癌的犬只的主人以及71只年龄和品种大小匹配、患有其他慢性疾病或肿瘤的对照犬只的主人那里获取了信息。膀胱癌风险与侧流香烟烟雾和家庭化学物质暴露无关。使用局部杀虫剂会显著增加风险（每年使用1 - 2次时，比值比为1.6；每年使用超过2次时，比值比为3.5；卡方趋势检验；p = 0.008）。在超重或肥胖的犬只中，这种风险会更高。对这种犬类模型的进一步研究可能有助于识别宠物动物常用杀虫剂以及环境中存在的特定致癌物。
