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Int J Clin Exp Med. 2015 Feb 15;8(2):2212-8. eCollection 2015.
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Rauwolfia polysaccharide can inhibit the progress of ulcerative colitis through NOS2-mediated JAK2/STAT3 pathway.萝芙木多糖可通过 NOS2 介导的 JAK2/STAT3 通路抑制溃疡性结肠炎的进展。
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Chemopreventive effects of 5-aminosalicylic acid on inflammatory bowel disease-associated colorectal cancer and dysplasia: a systematic review with meta-analysis.5-氨基水杨酸对炎症性肠病相关结直肠癌和发育异常的化学预防作用：一项荟萃分析的系统评价
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本文引用的文献

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Optimal bowel cleansing for colonoscopy: split the dose! A series of meta-analyses of controlled studies.结肠镜检查的最佳肠道准备：分剂量给药！一系列对照研究的荟萃分析。
Gastrointest Endosc. 2014 Oct;80(4):566-576.e2. doi: 10.1016/j.gie.2014.05.320. Epub 2014 Jul 19.
2
[Chemoprevention of colorectal cancer in inflammatory bowel disease].[炎症性肠病中结直肠癌的化学预防]
Korean J Gastroenterol. 2014 Jan 25;63(1):3-10. doi: 10.4166/kjg.2014.63.1.3.
3
5-Aminosalicylic acid and chemoprevention: does it work?5-氨基水杨酸与化学预防：它有效吗？
Dig Dis. 2013;31(2):248-53. doi: 10.1159/000353806. Epub 2013 Sep 6.
4
Development and validation of a scoring system to identify individuals at high risk for advanced colorectal neoplasms who should undergo colonoscopy screening.开发并验证一种评分系统，以识别出高危进展性结直肠肿瘤的个体，这些个体应接受结肠镜筛查。
Clin Gastroenterol Hepatol. 2014 Mar;12(3):478-85. doi: 10.1016/j.cgh.2013.08.042. Epub 2013 Sep 8.
5
5-aminosalicylic acid interferes in the cell cycle of colorectal cancer cells and induces cell death modes.5-氨基水杨酸干扰结直肠癌细胞的细胞周期并诱导细胞死亡方式。
Inflamm Bowel Dis. 2010 Mar;16(3):379-89. doi: 10.1002/ibd.21086.
6
Mesalamine protects against colorectal cancer in inflammatory bowel disease.美沙拉嗪可预防炎症性肠病中的结直肠癌。
Dig Dis Sci. 2010 Jun;55(6):1696-703. doi: 10.1007/s10620-009-0942-x. Epub 2009 Aug 25.
7
Progression to colorectal neoplasia in ulcerative colitis: effect of mesalamine.溃疡性结肠炎进展为结直肠肿瘤：美沙拉嗪的作用
Clin Gastroenterol Hepatol. 2008 Nov;6(11):1225-30; quiz 1177. doi: 10.1016/j.cgh.2008.05.020. Epub 2008 Oct 9.
8
Mesalazine negatively regulates CDC25A protein expression and promotes accumulation of colon cancer cells in S phase.美沙拉嗪负向调节细胞周期蛋白磷酸酶25A（CDC25A）蛋白表达，并促进结肠癌细胞在S期的积累。
Carcinogenesis. 2008 Jun;29(6):1258-66. doi: 10.1093/carcin/bgn122. Epub 2008 May 20.
9
Cancer in patients with ulcerative colitis, Crohn's disease and coeliac disease: record linkage study.溃疡性结肠炎、克罗恩病和乳糜泻患者的癌症：记录链接研究。
Eur J Gastroenterol Hepatol. 2008 Apr;20(4):297-304. doi: 10.1097/MEG.0b013e3282f2a5e2.
10
5-aminosalicylic acid given in the remission stage of colitis suppresses colitis-associated cancer in a mouse colitis model.在小鼠结肠炎模型中，在结肠炎缓解期给予5-氨基水杨酸可抑制结肠炎相关癌症。
Clin Cancer Res. 2007 Nov 1;13(21):6527-31. doi: 10.1158/1078-0432.CCR-07-1208.

5-氨基水杨酸对炎症性肠病相关结肠癌和结肠发育异常的化学预防作用：一项荟萃分析。

Chemopreventive effects of 5-amino salicylic acids on inflammatory bowel disease-associated colonic cancer and colonic dysplasia: a meta-analysis.

作者信息

Xu Xiaorong, Xu Xuanfu, Ciren Yangzong, Feng Baisui, Tao Chunhua, Xia Yujing, Liu Zhanju

机构信息

Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University No. 301 Yanchang Road, Shanghai 200072, China.

Department of Internal Medicine, The Second People's Hospital of Tibet Autonomous Region Lhasa, China.

出版信息

Int J Clin Exp Med. 2015 Feb 15;8(2):2212-8. eCollection 2015.

PMID:25932153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4402800/
Abstract

PURPOSE

To study the effects of 5-amino salicylic acids (5-ASAs) on the incidence rates of inflammatory bowel disease (IBD)-associated colonic cancer (IBDACa) and colonic dysplasia (IBDADys), as well as to evaluate the chemopreventive effects of 5-ASAs on IBDACa/Dys.

METHODS

Searches for officially published clinical studies on the effects of 5-ASAs on the chemoprevention of IBDACa/Dys were conducted in both foreign-language databases, including PubMed (Medline), EMCC, OVID, and the Cochrane Library, and Chinese databases, including Wanfang, Weipu (VIP), and CNKI, as well as using Google Scholar. For literature matching the selection criteria, the statistical software RevMan was employed to calculate odds ratio (OR) values and 95% confidence intervals (CIs). Sub-group analysis was performed for different study design types and IBD types.

RESULTS

A total of fourteen papers were included in this study. The results of the analysis showed that compared with patients not using 5-ASAs, patients using 5-ASAs showed only 49% of the occurrence rate of IBDACa and IBDADys, OR = 0.49 (95% CI: 0.33-0.73). The OR of ulcerative colitis (UC) patients using 5-ASAs exhibiting UCCa/Dys was 0.44 (95% CI: 0.26-0.76).

CONCLUSION

The use of 5-ASAs exerts a chemopreventive effect against IBDACa/Dys.

摘要

目的

研究5-氨基水杨酸（5-ASA）对炎症性肠病（IBD）相关结肠癌（IBDACa）和结肠发育异常（IBDADys）发病率的影响，并评估5-ASA对IBDACa/Dys的化学预防作用。

方法

检索外语数据库，包括PubMed（Medline）、EMCC、OVID和Cochrane图书馆，以及中文数据库，包括万方、维普（VIP）和知网，同时使用谷歌学术搜索关于5-ASA对IBDACa/Dys化学预防作用的官方发表的临床研究。对于符合选择标准的文献，使用统计软件RevMan计算比值比（OR）值和95%置信区间（CI）。对不同研究设计类型和IBD类型进行亚组分析。

结果

本研究共纳入14篇论文。分析结果显示，与未使用5-ASA的患者相比，使用5-ASA的患者IBDACa和IBDADys的发生率仅为49%，OR = 0.49（95% CI：0.33 - 0.73）。使用5-ASA的溃疡性结肠炎（UC）患者发生UCCa/Dys的OR为0.44（95% CI：0.26 - 0.76）。

结论

使用5-ASA对IBDACa/Dys具有化学预防作用。