Xue Hui-Chao, Li Ze-Xin, Zheng Wei-Wei, Guo Yun-Zhen, Feng De-Yuan, Liu Jiang-Wei
First Division, Department of General Surgery, The First Affiliated Hospital of Xinxiang Medical University Weihui 453100, China.
Department of Hepatobiliary Surgery, Urumqi General Hospital of Lanzhou Military Region Urumqi 830000, China.
Int J Clin Exp Med. 2015 Feb 15;8(2):2273-8. eCollection 2015.
This study aims to observe the changes of myocardial injuries after the firearm wound-induced intestinal perforation in porcine abdomen. 42 healthy Landrace piglets were randomly divided into the control group and the injury group, which was then subdivided into the post-injury 1 h, 2 h, 4 h, 8 h, 12 h and 24 h subgroup. the LDH, CK and CK-MB levels of each group, as well as the plasma endotoxin, were determined and compared. The plasma endotoxin levels of the experimental groups were significantly higher than the control group, and the light microscope observation revealed that the 8 h, 12 h and 24 h subgroup appeared the gradually-aggravated myocardial cell edema and degeneration; the electron microscope revealed that the 4 h, 8 h, 12 h and 24 h subgroup appeared the mitochondrial swelling and dissolution gradually; the serum levels of LDH, CK and CK-MB of each experimental group were higher than the control group. The abdominal firearm wound-induced intestinal perforation would lead to the damaged changes of myocardial morphology and enzymes, which would aggravate as time went along.
本研究旨在观察猪腹部火器伤致肠穿孔后心肌损伤的变化。将42只健康的长白仔猪随机分为对照组和损伤组，损伤组再分为伤后1小时、2小时、4小时、8小时、12小时和24小时亚组。测定并比较各组的乳酸脱氢酶（LDH）、肌酸激酶（CK）和肌酸激酶同工酶（CK-MB）水平以及血浆内毒素水平。实验组的血浆内毒素水平显著高于对照组，光镜观察显示8小时、12小时和24小时亚组出现心肌细胞水肿和变性逐渐加重；电镜显示4小时、8小时、12小时和24小时亚组出现线粒体逐渐肿胀和溶解；各实验组血清LDH、CK和CK-MB水平均高于对照组。腹部火器伤致肠穿孔会导致心肌形态和酶的损伤性变化，且会随时间推移而加重。
