冠心病患者的磁心动图诊断结果

Diagnostic outcomes of magnetocardiography in patients with coronary artery disease.

作者信息

Li Yingmei, Che Zaiqian, Quan Weiwei, Yuan Rong, Shen Yue, Liu Zongjun, Wang Weiqing, Jin Huigen, Lu Guoping

机构信息

Department of Geratology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine Shanghai 200062, China.

Department of Emergency, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine Shanghai 200025, China.

出版信息

Int J Clin Exp Med. 2015 Feb 15;8(2):2441-6. eCollection 2015.

PMID:25932186

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4402833/

Abstract

OBJECTIVE

To evaluate the diagnostic outcomes of magnetocardiography (MCG) on the patients with coronary artery disease and compared the outcomes between MCG, ECG and Echocardiography.

METHODS

MCG measurements were performed on 101 patients with coronary artery disease and 116 healthy volunteers with a seven-channel magnetocardiographic system (MCG7, SQUID AG, Germany) installed in an unshielded room. CAD was diagnosed when stenosis ≥ 70% in ≥ 1 vessel. Three quantitative indicators were analyzed, R-max/T-max ratio, R value and á average angle.

RESULTS

R-max/T-max ratio of CAD group (6.30 ± 4.07) was much higher than that of healthy group (3.73 ± 1.41) (P < 0.001), R value of CAD group (69.16 ± 27.87)% was significantly higher than that of healthy group (34.96 ± 19.09)% (P < 0.001), á average angle of CAD group (221.46° ± 64.53°) was higher than that of healthy group (24.32° ± 20.70°) (P < 0.01). In 75 of 101 CAD patients (74.26%), MCG had abnormal mapping patterns. The resting ECG examination showed ischemic changes, such as abnormal Q waves and ST-T change in 49 patients (48.51%). Echocardiography revealed abnormal left ventricular wall motion and asynergy in 46 patients (45.54%). Thus, the diagnostic outcomes of MCG for the patients with CAD were much significant than those of ECG and echocardiography (P < 0.001).

CONCLUSIONS

Our result showed that resting MCG under condition of an advanced data analysis has higher diagnostic outcomes and is superior to ECG or echocardiography for patients with CAD. MCG can detect ST-segment displacement caused by ischemic myocardium, thus helpful in diagnosing coronary artery disease early.

摘要

目的

评估磁心动图（MCG）对冠心病患者的诊断效果，并比较MCG、心电图（ECG）和超声心动图的诊断结果。

方法

使用安装在非屏蔽房间的七通道磁心动图系统（MCG7，德国SQUID AG公司）对101例冠心病患者和116名健康志愿者进行MCG测量。当≥1支血管狭窄≥70%时诊断为冠心病。分析了三个定量指标，即R-max/T-max比值、R值和α平均角度。

结果

冠心病组的R-max/T-max比值（6.30±4.07）远高于健康组（3.73±1.41）（P<0.001），冠心病组的R值（69.16±27.87）%显著高于健康组（34.96±19.09）%（P<0.001），冠心病组的α平均角度（221.46°±64.53°）高于健康组（24.32°±20.70°）（P<0.01）。101例冠心病患者中有75例（74.26%）MCG映射模式异常。静息心电图检查显示49例患者（48.51%）有缺血性改变，如异常Q波和ST-T改变。超声心动图显示46例患者（45.54%）左心室壁运动和协同运动异常。因此，MCG对冠心病患者的诊断结果比ECG和超声心动图更显著（P<0.001）。