STAT4基因rs7574865多态性与1型糖尿病风险相关：一项荟萃分析
STAT4 rs7574865 polymorphism contributes to the risk of type 1 diabetes: a meta analysis.
作者信息
Li Chaolin, Zhao Lujie, Wang Wei, Li Huafeng, Meng Xiaomei, Chen Shulin
机构信息
Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250000, Shandong, China ; Department of Endocrinology, Yantai Yuhuangding Hospital Affiliated to Qingdao University Yantai 264000, China.
Hemodialysis Center, Yantai Yuhuangding Hospital Affiliated to Qingdao University Yantai 264000, China.
出版信息
Int J Clin Exp Med. 2015 Feb 15;8(2):2471-5. eCollection 2015.
The signal transducer and activator of transcription 4 (STAT4) rs7574865 polymorphism has been indicated to be correlated with type 1 diabetes (T1D) susceptibility, but study results are still debatable. Thus, a meta-analysis was conducted. The electronic databases PubMed, Embase, CNKI, and Web of Science (ISI) were searched to find eligible studies. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. A significant association was found between STAT4 rs7574865 polymorphism and T1D risk (OR=1.30; 95% CI, 1.13-1.48; P<0.01; I(2) =73%). Significant associations were also found in Asians (OR=1.33; 95% CI, 1.04-1.71; P=0.02; I(2) =60%) and Caucasians (OR=1.26; 95% CI, 1.08-1.47; P<0.01; I(2) =74%), respectively. This association was also positive in the pediatric patients (OR=1.41; 95% CI, 1.19-1.68; P<0.01; I(2) =46%). Moreover, we found that STAT4 rs7574865 polymorphism was associated with early-onset T1D risk (OR=1.43; 95% CI, 1.16-1.77; P<0.01; I(2) =0%). This meta-analysis suggested that the STAT4 rs7574865 polymorphism may be associated with T1D development.
信号转导及转录激活因子4（STAT4）基因rs7574865多态性已被指出与1型糖尿病（T1D）易感性相关，但研究结果仍存在争议。因此，进行了一项荟萃分析。检索电子数据库PubMed、Embase、中国知网（CNKI）和科学网（ISI）以查找符合条件的研究。提取数据并计算合并比值比（OR）及95%置信区间（CI）。发现STAT4基因rs7574865多态性与T1D风险之间存在显著关联（OR = 1.30；95% CI，1.13 - 1.48；P < 0.01；I² = 73%）。在亚洲人（OR = 1.33；95% CI，1.04 - 1.71；P = 0.02；I² = 60%）和高加索人（OR = 1.26；95% CI，1.08 - 1.47；P < 0.01；I² = 74%）中也分别发现了显著关联。这种关联在儿科患者中也呈阳性（OR = 1.41；95% CI，1.19 - 1.68；P < 0.01；I² = 46%）。此外，我们发现STAT4基因rs7574865多态性与早发型T1D风险相关（OR = 1.43；95% CI，1.16 - 1.77；P < 0.01；I² = 0%）。这项荟萃分析表明，STAT4基因rs7574865多态性可能与T1D的发生发展相关。
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