降钙素对腰椎管狭窄症的影响：一项系统评价与荟萃分析
Effects of calcitonin on lumbar spinal stenosis: a systematic review and meta-analysis.
作者信息
Peng Kun, Chen Long, Peng Jing, Xing Fei, Xiang Zhou
机构信息
Department of Orthopaedics, West China Hospital, Sichuan University Chengdu 610041, Sichuan, China.
出版信息
Int J Clin Exp Med. 2015 Feb 15;8(2):2536-44. eCollection 2015.
Abstract
BACKGROUND
To investigate whether calcitonin can improve walking distance (WD) and visual analog pain scale (VAS) in patients who suffer lumbar spinal stenosis (LSS).
METHODS
We performed a search on CENTRAL, PubMed, Embase and Cochrane databases up to July 2014; we finally found 19 original articles, of which only 6 were in full compliance with the RCT criteria. These full articles were carefully reviewed independent and in blinded way by two previously capacitated reviewers for the objective to extract data and score a quality of these articles by the criteria of Cochrane Handbook (5.1.0).
RESULTS
We accepted 6 studies with 232 participants. There is no evidence show calcitonin is better than placebo or paracetamol regardless of mode of administration.
CONCLUSIONS
This meta-analysis suggest that calcitonin provide no significant improvement in pain symptoms or walking distance in LSS patients.
摘要
背景
探讨降钙素能否改善腰椎管狭窄症（LSS）患者的步行距离（WD）和视觉模拟疼痛量表（VAS）评分。
方法
检索截至2014年7月的CENTRAL、PubMed、Embase和Cochrane数据库；最终找到19篇原始文章，其中仅6篇完全符合随机对照试验（RCT）标准。两名经验丰富的审阅者以独立且盲法的方式仔细审阅这些全文，目的是提取数据并根据《Cochrane手册》（5.1.0）标准对这些文章的质量进行评分。
结果
我们纳入了6项研究，共232名参与者。无论给药方式如何，均无证据表明降钙素比安慰剂或对乙酰氨基酚更有效。
结论
这项荟萃分析表明，降钙素对LSS患者的疼痛症状或步行距离无显著改善作用。
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