血管紧张素转换酶基因多态性与糖尿病肾病易感性的关联。
Association of ACE polymorphism and diabetic nephropathy susceptibility.
作者信息
Ma Hongbo, Yu Che, Wang Rong
机构信息
Department of Nephrology, Shandong Provincial Hospital Affiliated to Shandong University Shandong, Jinan 250021, China.
出版信息
Int J Clin Exp Med. 2015 Feb 15;8(2):2962-5. eCollection 2015.
AIM
The study was aimed to analyze whether ACE rs267604983 polymorphism was related to the onset of diabetic nephropathy (DN).
METHODS
80 DN patients and 78 healthy controls were enrolled in the study. The differences of age, sex, body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure (DBP) between two groups were analyzed. The genotyping of ACE rs267604983 was conducted by the technology of PCR-HRM. Odds ratio (ORs) with 95% CI were used to evaluate the relationship of ACE rs267604983 with DN susceptibility.
RESULTS
The AA genotype of ACE rs267604983 was remarkably associated with the risk for DN (OR = 2.90, 95% CI = 1.12-7.51). In addition, for the A allele carriers, the risk for DN increased 1.87 fold (OR = 1.87, 95% CI = 1.16-3.01). The subgroup analysis showed that the AA genotype was found higher in normal albuminuria group than other groups (P = 0.006), while AG genotype was higher in macro albuminuria group (P = 0.036).
CONCLUSION
ACE rs267604983 polymorphism is associated with the risk of DN. AA genotype and A allele may increase the risk for DN. Furthermore, AA and AG genotypes may have effects on the subgroups of DN.
目的
本研究旨在分析血管紧张素转换酶（ACE）基因rs267604983多态性与糖尿病肾病（DN）发病是否相关。
方法
本研究纳入80例DN患者和78例健康对照。分析两组之间年龄、性别、体重指数（BMI）、收缩压（SBP）和舒张压（DBP）的差异。采用聚合酶链反应-高分辨率熔解曲线分析（PCR-HRM）技术对ACE基因rs267604983进行基因分型。采用比值比（OR）及95%置信区间（CI）评估ACE基因rs267604983与DN易感性的关系。
结果
ACE基因rs267604983的AA基因型与DN风险显著相关（OR = 2.90，95%CI = 1.12 - 7.51）。此外，对于A等位基因携带者，DN风险增加1.87倍（OR = 1.87，95%CI = 1.16 - 3.01）。亚组分析显示，正常蛋白尿组的AA基因型高于其他组（P = 0.006），而大量蛋白尿组的AG基因型较高（P = 0.036）。
结论
ACE基因rs267604983多态性与DN风险相关。AA基因型和A等位基因可能增加DN风险。此外，AA和AG基因型可能对DN亚组有影响。
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