Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Clinical Laboratory, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Haidian District, Beijing 100142, People's Republic of China.
Med Oncol. 2013 Mar;30(1):470. doi: 10.1007/s12032-013-0470-6. Epub 2013 Jan 24.
Lysosome-associated protein transmembrane-4 beta (LAPTM4B) is a novel cancer-related gene. It has two alleles designated LAPTM4B 1 and LAPTM4B 2. Previous studies have revealed that LAPTM4B polymorphisms contribute to the risk of many cancers. The aim of this study was to investigate the association between different LAPTM4B alleles and the risk of nasopharyngeal carcinoma (NPC), one of the most common cancers in southern China. Using polymerase chain reaction (PCR) in a case-control study, we detected the LAPTM4B genotype in peripheral blood samples from 134 patients with NPC and 327 control subjects. The chi-square test was used to analyze differences of categorical variables and Hardy-Weinberg equilibrium. Odds ratios and 95 % CI were computed using an unconditional logistic regression model. The frequency of allele 2 was 26.87 % in the NPC group, which was not significantly different from that of the control group (27.98 %, P = 0.867). Using the LAPTM4B 1/1 genotype as a reference, we found that the 1/2, 2/2 and 1/2 + 2/2 genotype were also not associated with the risk of NPC. No association was observed between LAPTM4B gene polymorphisms and the risk of NPC adjusted by gender and age. The results of our study indicated that the polymorphism of LAPTM4B gene did not influence the susceptibility of NPC in the Chinese population. Large-scale studies are needed to confirm our findings.
溶酶体相关蛋白跨膜 4β（LAPTM4B）是一种新的癌症相关基因。它有两个等位基因，分别命名为 LAPTM4B1 和 LAPTM4B2。先前的研究表明，LAPTM4B 多态性与许多癌症的风险有关。本研究旨在探讨不同 LAPTM4B 等位基因与中国南方最常见的癌症之一鼻咽癌（NPC）风险之间的关系。在病例对照研究中使用聚合酶链反应（PCR），我们检测了 134 例 NPC 患者和 327 例对照者外周血样本中的 LAPTM4B 基因型。使用卡方检验分析分类变量和 Hardy-Weinberg 平衡的差异。使用无条件逻辑回归模型计算比值比和 95%置信区间。NPC 组中等位基因 2 的频率为 26.87%，与对照组（27.98%，P=0.867）无显著差异。以 LAPTM4B1/1 基因型为参考，我们发现 1/2、2/2 和 1/2+2/2 基因型也与 NPC 风险无关。对性别和年龄进行调整后，LAPTM4B 基因多态性与 NPC 风险之间也没有关联。本研究结果表明，LAPTM4B 基因多态性不影响中国人群 NPC 的易感性。需要进行大规模研究来证实我们的发现。
