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双侧同步性乳腺癌——1例罕见病例报告

Bilateral synchronous carcinoma breast- a rare case presentation.

作者信息

Kappikeri Vijay Kumar Shankarrao, Kriplani Akshay Mahesh

机构信息

Department of Surgery, M.R. Medical College, Sedam Road, Gulbarga, Karnataka 585101 India.

出版信息

Springerplus. 2015 Apr 22;4:193. doi: 10.1186/s40064-015-0953-3. eCollection 2015.

Abstract

INTRODUCTION

Bilateral Breast Carcinoma (BBC) is a rare entity with incidence of synchronous carcinoma being 2-5% of all breast malignancies, which is much less than metachronous carcinoma. Synchronicity/ metachronicity are usually associated with local and lymphatic spread and with blood-borne spread to lungs, bones and liver. Moreover BBC are mostly lobular carcinomas but we report a rare case of Infiltrating Ductal Carcinoma (IDC) as the primary carcinoma and Lobular Carcinoma as the secondary.

CASE DESCRIPTION

56 year old female who presented with a Stage IIIB fungating growth around 10x8cm in the lower inner, lower outer and upper outer quadrant of right breast since 6 months and a StageIIA 4x4cm tumour felt in the left breast in the upper inner and lower outer quadrant. Wedge biopsy of the right breast fungating mass showed Ductal Carcinoma and FNAC of the left breast lump suggested Lobular carcinoma which was confirmed on Histopathology after surgery. Patient was subjected to Hormonal therapy (Tab Tamoxifen), chemotherapy (Cyclophosphamide, 5 FU, and Doxorubicin) followed by Radiotherapy. Patient recovered well and shows no recurrence or signs of metastasis in the 8 months of follow up.

DISCUSSION AND EVALUATION

Different histological subtypes with different grades of tumour in both breasts suggested two different synchronous primary tumours. Early detection of the contralateral tumour is of utmost importance emphasising the significance of breast self-examination. Screening tools like MRI have a greater sensitivity compared to Mammography. There are no clear treatment guidelines for bilateral breast cancer. Patients are often treated with bilateral mastectomy, with breast conservative surgery having unclear importance.

CONCLUSION

Meticulous diagnosis and appropriate management help to improve the longitivity with an improved quality of life.

摘要

引言

双侧乳腺癌(BBC)是一种罕见的疾病,同时性癌的发病率占所有乳腺恶性肿瘤的2%-5%,远低于异时性癌。同时性/异时性通常与局部及淋巴扩散以及血行转移至肺、骨和肝脏有关。此外,BBC大多为小叶癌,但我们报告了1例罕见病例,以浸润性导管癌(IDC)为原发性癌,小叶癌为继发性癌。

病例描述

一名56岁女性,6个月来右乳内下、外下和外上象限出现一个10×8cm的III B期溃疡性肿物,左乳内上和外下象限可触及一个4×4cm的II A期肿瘤。右乳溃疡性肿物楔形活检显示为导管癌,左乳肿块细针穿刺活检提示为小叶癌,术后组织病理学检查得以证实。患者接受了激素治疗(他莫昔芬片)、化疗(环磷酰胺、5-氟尿嘧啶和阿霉素),随后进行了放疗。患者恢复良好,在8个月的随访中未出现复发或转移迹象。

讨论与评估

双侧乳房不同组织学亚型及不同肿瘤分级提示为两个不同的同时性原发性肿瘤。对侧肿瘤的早期检测至关重要,强调了乳房自我检查的重要性。与乳腺钼靶相比,MRI等筛查工具具有更高的敏感性。目前尚无明确的双侧乳腺癌治疗指南。患者常接受双侧乳房切除术,保乳手术的重要性尚不明确。

结论

细致的诊断和恰当的管理有助于提高生存率并改善生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4419/4408308/0efdd514c35a/40064_2015_953_Fig1_HTML.jpg

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