Chaudary M A, Millis R R, Hoskins E O, Halder M, Bulbrook R D, Cuzick J, Hayward J L
Br J Surg. 1984 Sep;71(9):711-4. doi: 10.1002/bjs.1800710924.
A prospective study was carried out, between January 1980 and March 1982, of all women who presented to the Breast Cancer Unit, Guy's Hospital, with a second primary breast cancer. The percentage of new simultaneous tumours detected clinically or by mammography was approximately 3 per cent. Routine mammographic screening of the contralateral breasts of patients with unilateral disease increased the rate of detection, fivefold, of simultaneous bilateral cancers. The incidence of nonsimultaneous bilateral disease was 7.6 second cancers per thousand patients at risk per year. The annual rate of occurrence of second primary cancers was a constant event and showed no trend either to increase or to decrease with follow-up. However, the risk of a nonsimultaneous second cancer was strongly correlated with age at first primary. Women who developed their first breast cancers under the age of 40 years had three times the risk of developing a second breast cancer compared with those who developed their first cancer after the age of 40. The risk of a second nonsimultaneous primary was 5.9 times that of the risk of occurrence of cancer in the first breast in the general female population.
1980年1月至1982年3月期间，对所有前往盖伊医院乳腺癌科就诊的患第二原发性乳腺癌的女性进行了一项前瞻性研究。临床检查或乳房X光检查发现的新的同时性肿瘤的比例约为3%。对单侧疾病患者的对侧乳房进行常规乳房X光筛查，使同时性双侧癌症的检出率提高了五倍。非同时性双侧疾病的发病率为每年每千名有风险的患者中有7.6例第二癌症。第二原发性癌症的年发生率是一个恒定事件，随访期间没有增加或减少的趋势。然而，非同时性第二癌症的风险与首次原发性癌症的年龄密切相关。40岁以下患第一例乳腺癌的女性患第二例乳腺癌的风险是40岁以后患第一例癌症的女性的三倍。非同时性第二原发性癌症的风险是普通女性人群中第一例乳腺癌发生风险的5.9倍。
