Hypertension is a chronic condition that can lead to heart disease, stroke, and other diseases that can result in premature death. Reducing the number of persons in the population with hypertension is one of the objectives of Healthy People 2020. Using national multiple cause-of-death data files from the National Vital Statistics System, this report presents trends in hypertension-related mortality for 2000–2013 by selected demographic characteristics and the underlying causes of hypertension-related death. Hypertension-related mortality is defined by any mention of hypertension on the death certificate. Because about 2% of all decedents with hypertension reported on the death certificate were under age 45, only decedents aged 45 and over were included in this analysis.