人工细胞中的蛋白质合成：利用区室化实现囊泡生物反应器中的空间组织
Protein synthesis in artificial cells: using compartmentalisation for spatial organisation in vesicle bioreactors.
作者信息
Elani Yuval, Law Robert V, Ces Oscar
机构信息
Department of Chemistry, Imperial College London, Exhibition Road, SW7 2AZ, UK.
出版信息
Phys Chem Chem Phys. 2015 Jun 28;17(24):15534-7. doi: 10.1039/c4cp05933f. Epub 2015 May 1.
PMID:25932977
Abstract
Whereas spatial organisation of function is ubiquitous in biology, it has been lacking in artificial cells. We rectify this by using multi-compartment vesicles as chassis for artificial cells, allowing distinct biological processes to be isolated in space. This is demonstrated by in vitro synthesis of two proteins in predefined vesicle regions.
摘要
虽然功能的空间组织在生物学中无处不在，但在人工细胞中却一直缺乏。我们通过使用多隔室囊泡作为人工细胞的底盘来纠正这一问题，使不同的生物过程能够在空间中被分隔开。在预定义的囊泡区域中体外合成两种蛋白质就证明了这一点。
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