WestCHEM, School of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, U.K.
Org Lett. 2015 May 15;17(10):2514-7. doi: 10.1021/acs.orglett.5b01047. Epub 2015 May 1.
A novel, one-pot allylboration-Heck reaction of 2-bromobenzaldehydes has been developed for the general and efficient synthesis of 3-methyleneindan-1-ols. Modification of the one-pot procedure to include chiral Brønsted acid catalyzed allylation has allowed the preparation of these building blocks in high enantioselectivity and excellent yields.
一种新颖的、一锅法的烯丙基化-Heck 反应已经被开发出来，用于 2-溴苯甲醛的通用且高效的合成 3-亚甲基茚满-1-醇。对一锅法程序的修改，包括手性 Brønsted 酸催化的烯丙基化，使得这些砌块可以以高对映选择性和优异的收率制备。
