Hanif Farina M, Luck Nasir Hassan, Abbas Zaigham, Hassan Syed Mujahid, Shabir Sabhita, Mubarak Muhammad
Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation (SIUT), Karachi-74200.
Department of Histopathology, Sindh Institute of Urology and Transplantation (SIUT), Karachi-74200.
J Coll Physicians Surg Pak. 2015 Apr;25 Suppl 1:S14-6.
Celiac Disease (CD), also known as non-Tropical sprue, and Celiac sprue is an immune-mediated disorder, triggered by gluten containing grains in genetically susceptible people. The disease may be diagnosed at any age and can affect many organ systems. Its diagnosis and management can often be challenging. A high index of suspicion is required to diagnose this disease at an early stage in patients presenting with atypical symptomatology and delayed onset. Although serological tests are widely used, duodenal biopsy remains the gold standard for diagnosis of CD. Even though CD affects various body systems, Microscopic Colitis (MC) and refractory sprue are among the main gastrointestinal complications of CD, which are resistant to Gluten-Free Diet (GFD). A thorough and appropriate evaluation is mandatory for an early and accurate diagnosis of these complications. Herein, we report a case of a young female with CD in early phase in concordance with MC and splenomegaly.
乳糜泻（CD），也称为非热带性口炎性腹泻和乳糜泻口炎性腹泻，是一种免疫介导的疾病，由遗传易感人群摄入含麸质谷物引发。该疾病可在任何年龄被诊断出来，并且会影响多个器官系统。其诊断和管理常常具有挑战性。对于出现非典型症状和发病延迟的患者，早期诊断这种疾病需要高度的怀疑指数。尽管血清学检测被广泛使用，但十二指肠活检仍然是诊断乳糜泻的金标准。尽管乳糜泻会影响身体的各个系统，但显微镜下结肠炎（MC）和难治性口炎性腹泻是乳糜泻的主要胃肠道并发症，对无麸质饮食（GFD）有抗性。对这些并发症进行早期准确诊断，必须进行全面且恰当的评估。在此，我们报告一例处于疾病早期阶段且合并显微镜下结肠炎和脾肿大的年轻女性乳糜泻病例。
