巨噬细胞在接受有效抗逆转录病毒治疗的患者的HIV相关神经认知障碍及其他合并症中的作用。
Role of the macrophage in HIV-associated neurocognitive disorders and other comorbidities in patients on effective antiretroviral treatment.
作者信息
Rappaport Jay, Volsky David J
机构信息
Department of Neuroscience, Temple University School of Medicine, Medicine Education and Research Building-Room 746 MERB, 3500 N. Broad Street, Philadelphia, PA, 19140, USA,
出版信息
J Neurovirol. 2015 Jun;21(3):235-41. doi: 10.1007/s13365-015-0346-y. Epub 2015 May 2.
Abstract
Combination antiretroviral therapy (ART) has altered the outcomes of HIV infection in treated populations by greatly reducing the incidence of opportunistic infections, cancer, and HIV-associated dementia. Despite these benefits, treated patients remain at high risk of chronic diseases affecting the peripheral organs and brain. Generally, these morbidities are attributed to persistence of latent HIV in resting T cells, chronic inflammation, and metabolic effects of ART. This review makes the case that monocytes/macrophages warrant attention as persistent reservoirs of HIV under ART, source of systemic and brain inflammation, and important targets for HIV eradication to control chronic HIV diseases.
摘要
联合抗逆转录病毒疗法（ART）通过大幅降低机会性感染、癌症和与HIV相关的痴呆症的发病率，改变了接受治疗人群中HIV感染的结局。尽管有这些益处，但接受治疗的患者仍面临影响外周器官和大脑的慢性疾病的高风险。一般来说，这些发病率归因于静止T细胞中潜伏HIV的持续存在、慢性炎症以及ART的代谢作用。本综述表明，单核细胞/巨噬细胞作为ART治疗下HIV的持续储存库、全身和脑部炎症的来源以及根除HIV以控制慢性HIV疾病的重要靶点，值得关注。
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