Condés-Lara Miguel, Martínez-Lorenzana Guadalupe, Rubio-Beltrán Eloísa, Rodríguez-Jiménez Javier, Rojas-Piloni Gerardo, González-Hernández Abimael
Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, México.
Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, México.
Neurosci Res. 2015 Sep;98:59-63. doi: 10.1016/j.neures.2015.04.004. Epub 2015 Apr 28.
The hypothalamic paraventricular nuclei (PVN) inhibits spinal nociception. Furthermore, projections from the PVN to other structures related to pain modulation exist, but a functional interaction has not yet been fully demonstrated. As an initial approach, we show here that PVN electric stimulation with the same parameters used to induce analgesia in rats enhances c-Fos expression not only in the dorsal horn of the spinal cord but also in the nucleus raphe magnus, locus coeruleus and the periaqueductal gray area. These results suggest that a functional interaction between these structures could occur, possibly to assure a mechanism of endogenous analgesia.
下丘脑室旁核（PVN）抑制脊髓的痛觉感受。此外，PVN向其他与疼痛调节相关结构的投射是存在的，但尚未充分证明其功能相互作用。作为初步研究，我们在此表明，用与诱导大鼠镇痛相同的参数对PVN进行电刺激，不仅会增强脊髓背角中c-Fos的表达，还会增强中缝大核、蓝斑和导水管周围灰质区域中c-Fos的表达。这些结果表明，这些结构之间可能发生功能相互作用，这可能是为了确保内源性镇痛机制。
