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Identification of a fusion gene composed of a Hippo pathway gene MST2 and a common translocation partner ETV6 in a recurrent translocation t(8;12)(q22;p13) in acute myeloid leukemia.

作者信息

Ogawa Shinichi, Yokoyama Yasuhisa, Suzukawa Kazumi, Nanmoku Toru, Kurita Naoki, Seki Masanori, Maie Koichiro, Suyama Takuya, Takaiwa Naoko, Sakata-Yanagimoto Mamiko, Obara Naoshi, Hasegawa Yuichi, Chiba Shigeru

机构信息

Department of Hematology, University of Tsukuba Hospital, 1-1-1, Tennodai, Tsukuba, Ibaraki, Japan.

出版信息

Ann Hematol. 2015 Aug;94(8):1431-3. doi: 10.1007/s00277-015-2391-2. Epub 2015 May 3.

DOI:10.1007/s00277-015-2391-2
PMID:25933678
Abstract
摘要

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1
Identification of a fusion gene composed of a Hippo pathway gene MST2 and a common translocation partner ETV6 in a recurrent translocation t(8;12)(q22;p13) in acute myeloid leukemia.在急性髓系白血病的复发性易位t(8;12)(q22;p13)中鉴定出一个由Hippo通路基因MST2和常见易位伙伴ETV6组成的融合基因。
Ann Hematol. 2015 Aug;94(8):1431-3. doi: 10.1007/s00277-015-2391-2. Epub 2015 May 3.
2
Biallelic ETV6 rearrangements by recurrent translocations t(7;12)(p15;p13) and t(3;12)(q26.2;p13) in acute myeloid leukemia.急性髓系白血病中通过复发性易位t(7;12)(p15;p13)和t(3;12)(q26.2;p13)导致的双等位基因ETV6重排
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Disruption of the ETV6 gene as a consequence of a rare translocation (12;12)(p13;q13) in treatment-induced acute myeloid leukemia after breast cancer.乳腺癌治疗后发生的罕见易位(12;12)(p13;q13)导致ETV6基因破坏,引发急性髓系白血病。
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Variant of ETV6/ABL1 gene is associated with leukemia phenotype.ETV6/ABL1 基因突变与白血病表型相关。
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Heterogeneity of the 7q36 breakpoints in the t(7;12) involving ETV6 in infant leukemia.婴儿白血病中涉及ETV6的t(7;12)中7q36断点的异质性。
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引用本文的文献

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Hippo pathway-related genes expression is deregulated in myeloproliferative neoplasms.Hippo 通路相关基因表达在骨髓增殖性肿瘤中失调。
Med Oncol. 2022 May 23;39(5):97. doi: 10.1007/s12032-022-01696-x.
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New Insights into YES-Associated Protein Signaling Pathways in Hematological Malignancies: Diagnostic and Therapeutic Challenges.血液系统恶性肿瘤中Yes相关蛋白信号通路的新见解:诊断和治疗挑战
Cancers (Basel). 2021 Apr 20;13(8):1981. doi: 10.3390/cancers13081981.
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Knockdown of the Hippo transducer YAP reduces proliferation and promotes apoptosis in the Jurkat leukemia cell.
敲低 Hippo 转导蛋白 YAP 减少 Jurkat 白血病细胞的增殖并促进其凋亡。
Mol Med Rep. 2018 Dec;18(6):5379-5388. doi: 10.3892/mmr.2018.9556. Epub 2018 Oct 15.
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Cathepsin G is broadly expressed in acute myeloid leukemia and is an effective immunotherapeutic target.组织蛋白酶G在急性髓系白血病中广泛表达,是一种有效的免疫治疗靶点。
Leukemia. 2017 Jan;31(1):234-237. doi: 10.1038/leu.2016.249. Epub 2016 Aug 30.