Allegra Alessandro, Pioggia Giovanni, Innao Vanessa, Musolino Caterina, Gangemi Sebastiano
Department of Human Pathology in Adulthood and Childhood "Gaetano Barresi", Division of Hematology, University of Messina, 98125 Messina, Italy.
Institute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), 98164 Messina, Italy.
Cancers (Basel). 2021 Apr 20;13(8):1981. doi: 10.3390/cancers13081981.
The Hippo/YES-associated protein (YAP) signaling pathway is a cell survival and proliferation-control system with its main activity that of regulating cell growth and organ volume. YAP operates as a transcriptional coactivator in regulating the onset, progression, and treatment response in numerous human tumors. Moreover, there is evidence suggesting the involvement of YAP in the control of the hematopoietic system, in physiological conditions rather than in hematological diseases. Nevertheless, several reports have proposed that the effects of YAP in tumor cells are cell-dependent and cell-type-determined, even if YAP usually interrelates with extracellular signaling to stimulate the onset and progression of tumors. In the present review, we report the most recent findings in the literature on the relationship between the YAP system and hematological neoplasms. Moreover, we evaluate the possible therapeutic use of the modulation of the YAP system in the treatment of malignancies. Given the effects of the YAP system in immunosurveillance, tumorigenesis, and chemoresistance, further studies on interactions between the YAP system and hematological malignancies will offer very relevant information for the targeting of these diseases employing YAP modifiers alone or in combination with chemotherapy drugs.
河马/Yes相关蛋白（YAP）信号通路是一种细胞存活和增殖控制系统，其主要作用是调节细胞生长和器官体积。YAP作为转录共激活因子，在多种人类肿瘤的发生、发展及治疗反应中发挥作用。此外，有证据表明YAP在生理条件下而非血液系统疾病中参与造血系统的调控。然而，尽管YAP通常与细胞外信号相互作用以促进肿瘤的发生和发展，但已有多篇报道指出YAP在肿瘤细胞中的作用是细胞依赖性和细胞类型特异性的。在本综述中，我们报告了文献中关于YAP系统与血液系统肿瘤关系的最新研究结果。此外，我们评估了调节YAP系统在恶性肿瘤治疗中的潜在治疗用途。鉴于YAP系统在免疫监视、肿瘤发生和化疗耐药性方面的作用，进一步研究YAP系统与血液系统恶性肿瘤之间的相互作用，将为单独使用YAP调节剂或与化疗药物联合使用来靶向治疗这些疾病提供非常相关的信息。
