Hatch Jessica, Andreazza Ana, Olowoyeye Omodele, Rezin Gislane Tezza, Moody Alan, Goldstein Benjamin I
Sunnybrook Health Sciences Centre, Psychiatry, Toronto, ON, Canada; University of Toronto, Pharmacology & Toxicology, Toronto, ON, Canada.
University of Toronto, Psychiatry, Toronto, ON, Canada; Centre for Addiction and Mental Health, Toronto, ON, Canada.
J Psychosom Res. 2015 Sep;79(3):222-7. doi: 10.1016/j.jpsychores.2015.04.005. Epub 2015 Apr 20.
In the field of bipolar disorder (BD) research there is an absence of validated biomarkers and limited understanding of the biology underlying excessive and premature cardiovascular disease (CVD). Oxidative stress is a potential biomarker in both BD and CVD.
To examine psychiatric and cardiovascular characteristics associated with peripheral oxidative stress markers among adolescents with BD, who are at high risk for CVD.
Participants were 30 adolescents, 13-19years old, with BD and without CVD. Ultrasonography was used to evaluate vascular function and structure. Traditional CVD risk factors were also measured. Psychiatric assessments were conducted via semi-structured interview. Serum levels of oxidative stress (lipid hydroperoxides (LPH) and protein carbonylation (PC)) were assayed.
Compared to published data on adults with BD, adolescents had significantly lower levels of LPH and PC (t52(11.34), p<0.0001; t58(29.68), p<0.0001, respectively). Thicker mean and maximum carotid intima media thickness was associated with greater levels of LPH (r=.455, p=.015; r=.620, p<0.0001, respectively). LPH was associated with diastolic blood pressure (r=-.488, p=0.008) and pulse pressure (r=.543, p=0.003). Mood symptoms and medication were not significantly associated with oxidative stress.
Adolescents with BD have lower levels of oxidative stress compared to adults with BD, supporting prevailing illness staging theories for BD. Oxidative stress is robustly associated with a proxy measure of atherosclerosis and may explain in part the increased risk of CVD in BD.
在双相情感障碍（BD）研究领域，缺乏经过验证的生物标志物，对心血管疾病（CVD）过度和过早发生的生物学机制了解有限。氧化应激是BD和CVD的潜在生物标志物。
研究BD青少年（他们患CVD的风险很高）外周氧化应激标志物相关的精神和心血管特征。
参与者为30名13 - 19岁的BD青少年，且无CVD。采用超声检查评估血管功能和结构。还测量了传统的CVD危险因素。通过半结构化访谈进行精神评估。检测血清氧化应激水平（脂质过氧化产物（LPH）和蛋白质羰基化（PC））。
与已发表的BD成年患者数据相比，青少年的LPH和PC水平显著更低（分别为t52(11.34)，p<0.0001；t58(29.68)，p<0.0001）。平均和最大颈动脉内膜中层厚度增加与更高的LPH水平相关（分别为r=.455，p=.015；r=.620，p<0.0001）。LPH与舒张压（r=-.488，p=0.008）和脉压（r=.543，p=0.003）相关。情绪症状和药物治疗与氧化应激无显著关联。
与BD成年患者相比，BD青少年的氧化应激水平更低，这支持了BD流行的疾病分期理论。氧化应激与动脉粥样硬化的替代指标密切相关，可能部分解释了BD患者CVD风险增加的原因。
