Zhao Zhiming, Xi Hao, Xu Dabin, Li Chenggang
Department of Surgical Oncology, Chinese PLA General Hospital, Beijing, 100853, China.
Department of Surgical Oncology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
Tumour Biol. 2015 Sep;36(10):7711-6. doi: 10.1007/s13277-015-3466-3. Epub 2015 May 3.
Pancreatic ductal adenocarcinoma (PDAC) is extremely malignant. Efficient control of cancer growth may substantially improve the survival of PDAC patients. However, no efficient treatments are so far available. Here, we inhibited transforming growth factor β (TGFβ) receptor signaling by overexpression of a key inhibitor of this pathway, SMAD7, in the mouse pancreas, using a recently developed intraductal infusion method. Overexpression of SMAD7 significantly increased growth of both implanted PDAC and PDAC by K-ras modification. Our data thus suggest that TGFβ receptor signaling restrains growth of PDAC, and modulation of TGFβ receptor signaling may be an effective treatment for PDAC.
胰腺导管腺癌（PDAC）恶性程度极高。有效控制癌症生长可能会显著提高PDAC患者的生存率。然而，目前尚无有效的治疗方法。在此，我们使用最近开发的导管内灌注方法，通过在小鼠胰腺中过表达该信号通路的关键抑制剂SMAD7，来抑制转化生长因子β（TGFβ）受体信号传导。SMAD7的过表达显著增加了植入的PDAC以及经K-ras修饰的PDAC的生长。因此，我们的数据表明TGFβ受体信号传导会抑制PDAC的生长，调节TGFβ受体信号传导可能是治疗PDAC的有效方法。
