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讲给孙辈们听的己烯雌酚（乙底酚）的故事——跨代效应。

The history of Distilbène® (Diethylstilbestrol) told to grandchildren--the transgenerational effect.

作者信息

Fénichel Patrick, Brucker-Davis Françoise, Chevalier Nicolas

机构信息

Endocrinology-Diabetology and Reproduction Unit/Inserm U1065-C3M, Nice University Hospital, Nice, France.

Endocrinology-Diabetology and Reproduction Unit/Inserm U1065-C3M, Nice University Hospital, Nice, France.

出版信息

Ann Endocrinol (Paris). 2015 Jul;76(3):253-9. doi: 10.1016/j.ando.2015.03.008. Epub 2015 Apr 28.

DOI:10.1016/j.ando.2015.03.008
PMID:25934356
Abstract

The Distilbène® story is a dramatic episode which belongs to the history of medicine. It provided several useful lessons such as the importance of evidence-based medicine and the hazard to develop treatments during pregnancy without careful animal verifications. However, this experience has also provided unexpected progress by suggesting new pathophysiological concepts: fetal programming of adult diseases and/or transgenerational transmission of environmental effects through epigenetic modifications.

摘要

己烯雌酚的故事是医学史上一个引人注目的插曲。它提供了几个有益的教训，比如循证医学的重要性，以及在没有经过仔细动物验证的情况下在孕期开发治疗方法的危害。然而，这段经历也通过提出新的病理生理概念带来了意想不到的进展：成人疾病的胎儿编程和/或通过表观遗传修饰实现环境影响的跨代传递。

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