孕期暴露于己烯雌酚的女性的孙子辈中尿道下裂的流行情况：一项多代全国队列研究。
Prevalence of hypospadias in grandsons of women exposed to diethylstilbestrol during pregnancy: a multigenerational national cohort study.
机构信息
Unité d'Endocrinologie-Gynécologie Pédiatrique, Service de Pédiatrie I, Hôpital Arnaud de Villeneuve, CHU Montpellier and Université Montpellier, France.
出版信息
Fertil Steril. 2011 Jun 30;95(8):2574-7. doi: 10.1016/j.fertnstert.2011.02.047. Epub 2011 Apr 2.
Prenatal diethylstilbestrol (DES)-exposed mice have raised the suspicion of a transgenerational effect in the occurrence of genital malformation in males. This nationwide cohort study in collaboration with a French association of DES-exposed women studied 529 families and showed that a significant proportion of boys born to DES daughters exhibited hypospadias with no other molecular defects identified.
产前己烯雌酚（DES）暴露的小鼠引起了人们对雄性生殖畸形发生的跨代效应的怀疑。这项与法国 DES 暴露女性协会合作的全国性队列研究调查了 529 个家庭，结果表明，DES 女儿所生的男孩中，有相当一部分患有尿道下裂，但未发现其他分子缺陷。
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