Goyanes Alvaro, Robles Martinez Pamela, Buanz Asma, Basit Abdul W, Gaisford Simon
UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.
UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK; FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK.
Int J Pharm. 2015 Oct 30;494(2):657-663. doi: 10.1016/j.ijpharm.2015.04.069. Epub 2015 Apr 28.
The aim of this work was to explore the feasibility of combining hot melt extrusion (HME) with 3D printing (3DP) technology, with a view to producing different shaped tablets which would be otherwise difficult to produce using traditional methods. A filament extruder was used to obtain approx. 4% paracetamol loaded filaments of polyvinyl alcohol with characteristics suitable for use in fused-deposition modelling 3DP. Five different tablet geometries were successfully 3D-printed-cube, pyramid, cylinder, sphere and torus. The printing process did not affect the stability of the drug. Drug release from the tablets was not dependent on the surface area but instead on surface area to volume ratio, indicating the influence that geometrical shape has on drug release. An erosion-mediated process controlled drug release. This work has demonstrated the potential of 3DP to manufacture tablet shapes of different geometries, many of which would be challenging to manufacture by powder compaction.
这项工作的目的是探索将热熔挤出（HME）与3D打印（3DP）技术相结合的可行性，以期生产出使用传统方法难以制造的不同形状的片剂。使用细丝挤出机获得了含约4%对乙酰氨基酚的聚乙烯醇细丝，其特性适合用于熔融沉积建模3DP。成功地3D打印出了五种不同的片剂几何形状——立方体、棱锥体、圆柱体、球体和圆环体。打印过程未影响药物的稳定性。片剂的药物释放不取决于表面积，而是取决于表面积与体积之比，这表明几何形状对药物释放的影响。药物释放受侵蚀介导过程的控制。这项工作证明了3DP制造不同几何形状片剂的潜力，其中许多形状通过粉末压片制造具有挑战性。
