Bernatoniene Jurga, Stabrauskiene Jolita, Kazlauskaite Jurga Andreja, Bernatonyte Urte, Kopustinskiene Dalia Marija
Department of Drug Technology and Social Pharmacy, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, LT-50161 Kaunas, Lithuania.
Institute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, LT-50161 Kaunas, Lithuania.
Pharmaceutics. 2025 Mar 19;17(3):390. doi: 10.3390/pharmaceutics17030390.
Three-dimensional printing technology is transforming pharmaceutical manufacturing by shifting from conventional mass production to additive manufacturing, with a strong emphasis on personalized medicine. The integration of bioinks and AI-driven optimization is further enhancing this innovation, enabling drug production with precise dosages, tailored drug-release profiles, and unique multi-drug combinations that respond to individual patient needs. This advancement is significantly impacting healthcare by accelerating drug development, encouraging innovative pharmaceutical designs, and enhancing treatment efficacy. Traditional pharmaceutical manufacturing follows a one-size-fits-all approach, which often fails to meet the specific requirements of patients with unique medical conditions. In contrast, 3D printing, coupled with bioink formulations, allows for on-demand drug production, reducing dependency on large-scale manufacturing and storage. AI-powered design and process optimization further refine dosage forms, printability, and drug release mechanisms, ensuring precision and efficiency in drug manufacturing. These advancements have the potential to lower overall healthcare costs while improving patient adherence to medication regimens. This review explores the potential, challenges, and environmental benefits of 3D pharmaceutical printing, positioning it as a key driver of next-generation personalized medicine.
三维打印技术正在改变制药制造业,从传统的大规模生产转向增材制造,特别强调个性化医疗。生物墨水与人工智能驱动的优化相结合,进一步推动了这一创新,能够生产出剂量精确、药物释放曲线定制、独特的多药物组合且能满足个体患者需求的药物。这一进展通过加速药物研发、鼓励创新的药物设计以及提高治疗效果,对医疗保健产生了重大影响。传统制药制造采用一刀切的方法,往往无法满足患有特殊医疗状况患者的特定需求。相比之下,3D打印与生物墨水配方相结合,可实现按需生产药物,减少对大规模制造和储存的依赖。人工智能驱动的设计和工艺优化进一步完善剂型、可打印性和药物释放机制,确保药物制造的精确性和效率。这些进展有可能降低总体医疗成本,同时提高患者对药物治疗方案的依从性。本综述探讨了3D药物打印的潜力、挑战和环境效益,将其定位为下一代个性化医疗的关键驱动力。