Hamamoto Y, Kawarazaki S, Taniguchi T, Hashimoto K, Okada H, Nakashima M, Horii K, Nishiyama A
Kekkaku. 1989 Nov;64(11):713-9.
We reported a case of 64 a year-old male patient of miliary tuberculosis associated with ARDS, DIC and pneumothorax, who had a history of gastric ulcer and pulmonary tuberculosis. On admission his chief complaints were fever, fatigue, palpitation, appetite loss and weight loss, and most noticeable abnormalities were bleeding from the gastric ulcer and miliary shadow on the chest x-ray film with hypoxemia. On the day after admission to the hospital he was diagnosed as ARDS as he showed severe hypoxemia due to extensive tuberculous infiltration in bilateral lung fields, and treatment with antituberculous drugs and steroids were started. On the third hospital day DIC appeared on laboratory data, Gabexate mesilate (FOY) for DIC and respirator for ARDS were introduced. Two weeks later pulmonary infiltration, PaO2 and general condition were somewhat improved. On the 15th day after admission pneumothorax occurred on the right side, and on the 20th day on the left. Tube drainage of both pleural cavities, and instillation of OK-432 and Fibrinogen HT into the right pleural cavity were done, but it showed no effect. Two months after admission pouring Fibrinogen HT and thrombin into the left B1+2 and right B1 with cannula washing pipe through the instrument channel of bronchoscope was carried out. A few days later air leakage stopped and collapsed lungs were completely expanded. This method is effective in the case of incurable pneumothorax with pulmonary hypofunction.
我们报告了一例64岁男性粟粒型肺结核患者,该患者合并急性呼吸窘迫综合征(ARDS)、弥散性血管内凝血(DIC)和气胸,有胃溃疡和肺结核病史。入院时,他的主要症状为发热、乏力、心悸、食欲减退和体重减轻,最明显的异常是胃溃疡出血以及胸部X光片上的粟粒状阴影伴低氧血症。入院次日,由于双侧肺野广泛结核浸润导致严重低氧血症,他被诊断为ARDS,并开始使用抗结核药物和类固醇进行治疗。入院第三天,实验室检查结果显示出现了DIC,于是开始使用甲磺酸加贝酯(FOY)治疗DIC,并使用呼吸机治疗ARDS。两周后,肺部浸润、动脉血氧分压(PaO2)和一般状况有所改善。入院第15天,右侧发生气胸,第20天左侧也发生气胸。对双侧胸腔进行了胸腔闭式引流,并向右侧胸腔内注入了溶链菌制剂(OK-432)和纤维蛋白原HT,但未见效果。入院两个月后,通过支气管镜的器械通道,将纤维蛋白原HT和凝血酶经插管冲洗管注入左肺B1+2和右肺B1。几天后,漏气停止,萎陷的肺完全复张。这种方法对于伴有肺功能低下的难治性气胸有效。