Petherick Emily S, Pickett Kate E, Cullum Nicky A
Bradford Institute for Health Research, Bradford, School of Health Studies, University of Bradford, Bradford,
Department of Health Sciences, and Hull York Medical School, University of York, York and.
Fam Pract. 2015 Aug;32(4):374-80. doi: 10.1093/fampra/cmv013. Epub 2015 May 1.
Primary care databases from the UK have been widely used to produce evidence on the epidemiology and health service usage of a wide range of conditions. To date there have been few evaluations of the comparability of estimates between different sources of these data.
To estimate the comparability of two widely used primary care databases, the Health Improvement Network Database (THIN) and the General Practice Research Database (GPRD) using venous leg ulceration as an exemplar condition.
Cross prospective cohort comparison.
GPRD and the THIN databases using data from 1998 to 2006.
A data set was extracted from both databases containing all cases of persons aged 20 years or greater with a database diagnosis of venous leg ulceration recorded in the databases for the period 1998-2006. Annual rates of incidence and prevalence of venous leg ulceration were calculated within each database and standardized to the European standard population and compared using standardized rate ratios.
Comparable estimates of venous leg ulcer incidence from the GPRD and THIN databases could be obtained using data from 2000 to 2006 and of prevalence using data from 2001 to 2006.
Recent data collected by these two databases are more likely to produce comparable results of the burden venous leg ulceration. These results require confirmation in other disease areas to enable researchers to have confidence in the comparability of findings from these two widely used primary care research resources.
英国的基层医疗数据库已被广泛用于生成关于多种疾病的流行病学和卫生服务使用情况的证据。迄今为止，对这些数据不同来源的估计可比性进行的评估较少。
以静脉性腿部溃疡为例，评估两个广泛使用的基层医疗数据库——健康改善网络数据库（THIN）和全科医疗研究数据库（GPRD）的可比性。
交叉前瞻性队列比较。
使用1998年至2006年数据的GPRD和THIN数据库。
从两个数据库中提取一个数据集，其中包含1998 - 2006年期间数据库记录的所有年龄在20岁及以上且诊断为静脉性腿部溃疡的病例。在每个数据库中计算静脉性腿部溃疡的年发病率和患病率，并根据欧洲标准人群进行标准化，然后使用标准化率比进行比较。
使用2000年至2006年的数据可获得GPRD和THIN数据库中静脉性腿部溃疡发病率的可比估计值，使用2001年至2006年的数据可获得患病率的可比估计值。
这两个数据库收集的近期数据更有可能得出静脉性腿部溃疡负担的可比结果。这些结果需要在其他疾病领域得到证实，以便研究人员能够对这两个广泛使用的基层医疗研究资源的研究结果可比性有信心。
