Margolis David J, Bilker Warren, Santanna Jill, Baumgarten Mona
Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
J Am Acad Dermatol. 2002 Mar;46(3):381-6. doi: 10.1067/mjd.2002.121739.
Venous leg ulcer is a disease most common in those aged 65 years and older. However, the incidence and prevalence have not been well established.
Our purpose was to estimate the prevalence and incidence of venous leg ulcers in the elderly.
We studied the General Practice Research Database, validated our case ascertainment strategy, and estimated the annual prevalence and incidence of venous leg ulcer.
The positive predictive value of our ascertainment strategy was 98.3% (95% confidence interval [CI], 90.0, 100.0). The annual prevalence of venous leg ulcer among the elderly was 1.69 (95% CI, 1.65, 1.74). The overall incidence rate was 0.76 (95% CI, 0.71, 0.83) for men and 1.42 (1.35, 1.48) per 100 person-years for women.
Venous leg ulcer is a significant problem in those aged 65 years and older. As compared with previous studies, because we used medical records from a population of known size, our results are precise and less biased.
下肢静脉溃疡是一种在65岁及以上人群中最常见的疾病。然而，其发病率和患病率尚未得到充分确定。
我们的目的是估计老年人下肢静脉溃疡的患病率和发病率。
我们研究了全科医学研究数据库，验证了我们的病例确定策略，并估计了下肢静脉溃疡的年度患病率和发病率。
我们确定策略的阳性预测值为98.3%（95%置信区间[CI]，90.0，100.0）。老年人下肢静脉溃疡的年度患病率为1.69（95%CI，1.65，1.74）。男性的总体发病率为每百人年0.76（95%CI，0.71，0.83），女性为每百人年1.42（1.35，1.48）。
下肢静脉溃疡在65岁及以上人群中是一个重大问题。与以前的研究相比，由于我们使用了已知规模人群的医疗记录，我们的结果更精确且偏差更小。
